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- W1969134943 endingPage "1046" @default.
- W1969134943 startingPage "1033" @default.
- W1969134943 abstract "A Drosophila cDNA encoding the largest TFIID subunit (p230) was isolated using a degenerate oligodeoxynucleotide probe based on an amino acid sequence of the purified protein. The entire cDNA sequence contains an open reading frame encoding a polypeptide of 2068 amino acids, corresponding to a calculated molecular mass of 232 kD. The deduced amino acid sequence showed a strong sequence similarity with the protein encoded by a human gene (CCG1) implicated in cell cycle progression through G1, suggesting that p230 may be a target for cell cycle regulatory factors. The recombinant protein expressed in Sf9 cells via a baculovirus vector interacts directly with the TATA box-binding subunit of TFIID (TFIID tau or TBP) from Drosophila, human, and yeast. Surprisingly, recombinant p230 inhibits the TATA box-binding activity and function of TFIID tau, suggesting that p230 interactions with TFIID tau, and possible modulations thereof by other factors may play an important role in TFIID function." @default.
- W1969134943 created "2016-06-24" @default.
- W1969134943 creator A5007414333 @default.
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- W1969134943 date "1993-06-01" @default.
- W1969134943 modified "2023-09-26" @default.
- W1969134943 title "Drosophila 230-kD TFIID subunit, a functional homolog of the human cell cycle gene product, negatively regulates DNA binding of the TATA box-binding subunit of TFIID." @default.
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- W1969134943 doi "https://doi.org/10.1101/gad.7.6.1033" @default.
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