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• W1969135822 abstract "Endoreduplication or DNA replication without mitosis is widespread in nature. Well-known examples are fruit fly polytene chromosomes and cereal endosperm. Although endocycles are thought to be driven by the same regulators as those that control the G1-S transition of the mitotic cell cycle, the molecular mechanisms that differentiate mitotically dividing cells from endoreduplicating ones are largely unknown. A novel class of atypical E2F-like proteins has recently been identified and is designated E2F7 in mammals [1de Bruin A. Maiti B. Jakoi L. Timmers C. Buerki R. Leone G. Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation.J. Biol. Chem. 2003; 278: 42041-42049Crossref PubMed Scopus (157) Google Scholar, 2Di Stefano L. Jensen M.R. Helin K. E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes.EMBO J. 2003; 22: 6289-6298Crossref PubMed Scopus (193) Google Scholar] and DP-E2F-like (DEL) in Arabidopsis thaliana[3Vandepoele K. Raes J. De Veylder L. Rouzé P. Rombauts S. Inzé D. Genome-wide analysis of core cell cycle genes in Arabidopsis.Plant Cell. 2002; 14: 903-916Crossref PubMed Scopus (420) Google Scholar, 4Kosugi S. Ohashi Y. E2Ls, E2F-like repressors of Arabidopsis that bind to E2F sites in a monomeric form.J. Biol. Chem. 2002; 277: 16553-16558Crossref PubMed Scopus (72) Google Scholar, 5Mariconti L. Pellegrini B. Cantoni R. Stevens R. Bergounioux C. Cella R. Albani D. The E2F family of transcription factors from Arabidopsis thaliana. Novel and conserved components of the retinoblastoma/E2F pathway in plants.J. Biol. Chem. 2002; 277: 9911-9919Crossref PubMed Scopus (133) Google Scholar]. We demonstrate that loss of DEL1 function resulted in increased ploidy levels, whereas ectopic expression of DEL1 reduced endoreduplication. Ploidy changes were correlated with altered expression of a subset of E2F target genes encoding proteins necessary for DNA replication. Because DEL1 proteins were postulated to antagonize the E2F pathway, we generated DEL1-E2Fa-DPa triple transgenics. DEL1 inhibited the endoreduplication phenotype, but not the ectopic cell divisions that resulted from the overexpression of both E2Fa and DPa, illustrating that DEL1 specifically represses the endocycle. Because DEL1 transcripts were detected exclusively in mitotically dividing cells, we conclude that DEL1 is an important novel inhibitor of the endocycle and preserves the mitotic state of proliferating cells by suppressing transcription of genes that are required for cells to enter the DNA endoreduplication cycle." @default.
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• W1969135822 date "2005-01-01" @default.
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• W1969135822 title "The DP-E2F-like Gene DEL1 Controls the Endocycle in Arabidopsis thaliana" @default.
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• W1969135822 doi "https://doi.org/10.1016/j.cub.2004.12.038" @default.
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