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- W1969136723 abstract "Many compounds have been claimed to possess powerful taenicidal activity but only a few are able to remove the tapeworms complete with scolices; accordingly better drugs are still needed. A series of 3, 5-dibromosalicylanilides, possessing a molecular framework similar to that of niclosamide (Gönnert and Schraufstätter, 1960) was tested for taenicidal activity; the most potent anticestode compound was found to be 3, 5-dibromo-2' -chlorosalicylanilide-4' -isothiocyanate (CDRI Compound 77–6). The present communication compares the efficacy of Compound 77–6 with niclosamide, N-(2' -chloro-4-nitrophenyl)-5-chlorosalicylamid (Bayer, power with 75% active ingredient) and praziquantel, 2-cyclohexylcarbonyl-1–3, 4, 6, 7, 11 b-hexahydro-2H-Pyrazino [2–1-a], isoquinoline-4-one (Droncit, E. Merck & Bayer, powder, 100% pure) (Seubert et al. , 1977) in rats and mice." @default.
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- W1969136723 date "1980-12-01" @default.
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- W1969136723 title "Anticestode activity of 3, 5-dibromo-2' -chlorosalicylanilide-4' -isothiocyanate—a preliminary report" @default.
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- W1969136723 doi "https://doi.org/10.1017/s0022149x00006751" @default.
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