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- W1969137501 abstract "As most studies on pemphigus vulgaris (PV) pathogenesis concern its active stage, we aimed to evaluate the serum concentration of TNF-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>α</mml:mi></mml:math>, IL-1, and IL-6 in PV patients in clinical remission. The study group consisted of sera from 19 PV patients in active stage and from 24 patients in clinical remission. 19 sera taken from healthy subjects served as the controls. Serum IL-6 concentrations in PV active and PV remission group were significantly higher when compared to the controls<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mrow><mml:mo>(</mml:mo><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>.05</mml:mn></mml:mrow><mml:mo>)</mml:mo></mml:mrow></mml:mrow></mml:math>. In patients in active stage of PV, a significant correlation between serum IL-1 and IL-6 concentrations was found (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:msub><mml:mi>r</mml:mi><mml:mi>P</mml:mi></mml:msub><mml:mo>=</mml:mo><mml:mn>0.46</mml:mn><mml:mo>;</mml:mo><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>.05</mml:mn></mml:mrow></mml:math>). We also found a negative correlation between TNF-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>α</mml:mi></mml:math>level and pemphigus antibodies titer in the patients from the remission group (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:msub><mml:mi>r</mml:mi><mml:mi>S</mml:mi></mml:msub><mml:mo>=</mml:mo><mml:mo>−</mml:mo><mml:mn>0.47303</mml:mn><mml:mo>;</mml:mo><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>.02</mml:mn></mml:mrow></mml:math>). Our data suggest that IL-6 and TNF-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>α</mml:mi></mml:math>may be involved in maintaining immunological disturbances in remission stage of PV." @default.
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- W1969137501 date "2008-01-01" @default.
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- W1969137501 title "Serum Concentration of Interleukin-6 Is Increased Both in Active and Remission Stages of Pemphigus Vulgaris" @default.
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- W1969137501 doi "https://doi.org/10.1155/2008/875394" @default.
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