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• W1969137895 abstract "Abstract Background NIK ‐ and IKK 2‐binding protein ( NIBP )/ TRAPPC 9 is expressed in brain neurons, and human NIBP mutations are associated with neurodevelopmental disorders. The cellular distribution and function of NIBP in the enteric nervous system ( ENS ) remain unknown. Methods Western blot and reverse transcription‐polymerase chain reaction analysis were used respectively to identify the protein and mRNA expression of NIBP and other neuronal markers. Multi‐labeled immunofluorescent microscopy and confocal image analysis were used to examine the cellular distribution of NIBP ‐like immunoreactivity ( IR ) in whole mount intestine. Enteric neuronal cell line ( ENC ) was infected with lentivirus carrying NIBP or its sh RNA expression vectors and treated with vehicle or tumor necrosis factor ( TNF )α. Key Results NIBP is expressed at both mRNA and protein levels in different regions and layers of the mouse intestine. NIBP ‐like‐ IR was co‐localized with various neuronal markers, but not with glial, smooth muscular, or interstitial cells of C ajal markers. A small population of NIBP ‐expressing cells and fibers in extra‐ganglionic and intra‐ganglionic area were negative for pan‐neuronal markers HuD or Peripherin. Relatively high NIBP ‐like‐ IR was found in 35–44% of myenteric neurons and 9–10% of submucosal neurons. Approximately 98%, 87%, and 43% of these relatively high NIBP ‐expressing neurons were positive for choline acetyltransferase, neuronal nitric oxide synthase and Calretinin, respectively. NIBP sh RNA knockdown in ENC inhibited TNF α‐induced NF κB activation and neuronal differentiation, whereas NIBP overexpression promoted it. Conclusions & Inferences NIBP is extensively expressed in the ENS with relatively high level in a subpopulation of enteric neurons. Various NIBP expression levels in different neurons may represent dynamic trafficking or posttranslational modification of NIBP in some functionally active neurons and ultimately regulate ENS plasticity." @default.
• W1969137895 created "2016-06-24" @default.
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• W1969137895 date "2013-09-09" @default.
• W1969137895 modified "2023-10-17" @default.
• W1969137895 title "Expression and function of NIK- and IKK2-binding protein (NIBP) in mouse enteric nervous system" @default.
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• W1969137895 doi "https://doi.org/10.1111/nmo.12234" @default.
• W1969137895 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3962790" @default.
• W1969137895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24011459" @default.
• W1969137895 hasPublicationYear "2013" @default.
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