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- W1969138928 abstract "Abstract The development of the stearyl-CoA desaturase system was studied in newly hatched chicks. The desaturation activity was very low in hepatic microsomes from chick embryos, less than 0.05 nmol of oleate formed min−1 (mg of protein)−1. After hatching and feeding, the desaturation activity gradually increased to 4–5 nmol of oleate formed min−1 (mg of protein)−1 in 6-day-old chicks. This increase could be prevented by administration of cycloheximide or actinomycin D. Measurement of the microsomal electron transfer components throughout the induction period showed no significant changes in the NADH- or NADPH-specific reductases or in the concentrations of cytochromes b5 and P-450. However, the activity of the terminal component of the desaturase system (the desaturase enzyme) increased in parallel with the desaturation activity. Supplementing the liver microsomes from chick embryos with isolated desaturase enzyme resulted in the formation of an active desaturation system. It is proposed that the induction of the stearyl-CoA desaturase system during development of newly hatched chicks is dependent on the synthesis of the terminal desaturase enzyme." @default.
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- W1969138928 date "1976-03-01" @default.
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- W1969138928 title "Induction of microsomal stearyl coenzyme a desaturase in newly hatched chicks" @default.
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- W1969138928 doi "https://doi.org/10.1016/0003-9861(76)90245-9" @default.
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