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- W1969139750 abstract "The management of erectile dysfunction (ED) has been completely transformed with the advent of effective oral therapy that occurred after the introduction of sildenafil in 1999. However, until the mid-1990s, the only practical method of delivering vasoactive substances to the penile erectile tissues was by direct injection into the copora cavernosa. Despite the introduction of orally effective agents, intracavernosal injection (ICI) continues to enjoy widespread acceptance by patients and urologists alike. However, despite its initial acceptance as a treatment alternative, 31–80% of men using such therapies eventually discontinue treatment for reasons relating to pain, loss of effectiveness, aversion to self-injection, and lack of interest, with drop out rates approaching 50% at 1 yr. This de facto dissatisfaction with proven effective treatments is the rationale] for alternative routes for the delivery of vasoactive substances." @default.
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- W1969139750 date "2007-11-15" @default.
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- W1969139750 title "Topical and Intra-Urethral Therapy" @default.
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