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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969140160> ?p ?o ?g. }

• W1969140160 endingPage "2030" @default.
• W1969140160 startingPage "2021" @default.
• W1969140160 abstract "RNAi-based gene therapy for cancer treatment has not shown significant clinical impact due to poor siRNA delivery to the target site. Here, we design a nonviral siRNA gene carrier using a combination of an arginine-grafted bioreducible polymer (ABP), microbubbles (MB), and ultrasound (US), for targeting vascular endothelial growth factor (VEGF) in a human ovarian cancer cell line. Newly designed MBs with a perfluorocrownether gas core show higher stability compared to controls. Further, MBs in combination with polyplexes show a significant higher loading capacity compared to naked siRNA. Lastly, only siRNA-ABP-MB (SAM) complexes in combination with US show significant VEGF knock down in A2780 human ovarian cancer cell line compared to naked siRNA when incubated for a short time after sonication treatment." @default.
• W1969140160 created "2016-06-24" @default.
• W1969140160 creator A5045388136 @default.
• W1969140160 creator A5057258699 @default.
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• W1969140160 date "2013-04-05" @default.
• W1969140160 modified "2023-10-17" @default.
• W1969140160 title "Enhanced siRNA Delivery Using a Combination of an Arginine-Grafted Bioreducible Polymer, Ultrasound, and Microbubbles in Cancer Cells" @default.
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• W1969140160 doi "https://doi.org/10.1021/mp400048p" @default.
• W1969140160 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3646922" @default.
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• W1969140160 hasPublicationYear "2013" @default.
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