FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969155152> ?p ?o ?g. }

• W1969155152 endingPage "1552" @default.
• W1969155152 startingPage "1542" @default.
• W1969155152 abstract "The worldwide rise in the rates of antibiotic resistance of bacteria underlines the need for alternative antibacterial agents. A promising approach to the killing of gram-positive antibiotic-resistant bacteria of the skin uses light in combination with a photosensitizer to induce a phototoxic reaction. Different concentrations (0 to 100 microM) of porphyrin-based photosensitizers (CTP1, XF70, and XF73) and different incubation times (5 min, 1 h, and 4 h) were used to determine phototoxicity against two methicillin-resistant Staphylococcus aureus strains, one methicillin-sensitive S. aureus strain, one methicillin-resistant Staphylococcus epidermidis strain, one Escherichia coli strain, and human keratinocytes and fibroblasts. Incubation with 0.005 microM XF70 or XF73, followed by illumination, yielded a 3-log10 (> or = 99.9%) decrease in the viable cell numbers of all staphylococcal strains, indicating that the XF drugs have high degrees of potency against gram-positive bacteria and also that the activities of these novel drugs are independent of the antibiotic resistance pattern of the staphylococci examined. CTP1 was less potent against the staphylococci under the same conditions. At 0.005 microM, XF70 and XF73 demonstrated no toxicity toward fibroblasts or keratinocytes. No inactivation of E. coli was detected at this concentration. XF73 was confirmed to act via a reactive oxygen species from the results of studies with sodium azide (a quencher of singlet oxygen), which reduced the killing of both eukaryotic and prokaryotic cells. When a quencher of superoxide anion and the hydroxyl radical was used, cell killing was not inhibited. These results demonstrate that the porphyrin-based photosensitizers had concentration-dependent differences in their efficacies of killing of methicillin-resistant staphylococcal strains via reactive oxygen species without harming eukaryotic cells at the same concentrations." @default.
• W1969155152 created "2016-06-24" @default.
• W1969155152 creator A5002640669 @default.
• W1969155152 creator A5031159456 @default.
• W1969155152 creator A5040679537 @default.
• W1969155152 creator A5073877780 @default.
• W1969155152 creator A5091851420 @default.
• W1969155152 date "2005-04-01" @default.
• W1969155152 modified "2023-10-18" @default.
• W1969155152 title "Photodynamic Effects of Novel XF Porphyrin Derivatives on Prokaryotic and Eukaryotic Cells" @default.
• W1969155152 cites W1552886287 @default.
• W1969155152 cites W159209346 @default.
• W1969155152 cites W1655014852 @default.
• W1969155152 cites W1664689314 @default.
• W1969155152 cites W1963677613 @default.
• W1969155152 cites W1967312357 @default.
• W1969155152 cites W1968577485 @default.
• W1969155152 cites W1969747613 @default.
• W1969155152 cites W1970183062 @default.
• W1969155152 cites W1970586535 @default.
• W1969155152 cites W1978819577 @default.
• W1969155152 cites W1978821331 @default.
• W1969155152 cites W1979770903 @default.
• W1969155152 cites W1981678324 @default.
• W1969155152 cites W1981951234 @default.
• W1969155152 cites W1982188512 @default.
• W1969155152 cites W1986057738 @default.
• W1969155152 cites W1989114360 @default.
• W1969155152 cites W1993294422 @default.
• W1969155152 cites W2008028796 @default.
• W1969155152 cites W2011004608 @default.
• W1969155152 cites W2017533593 @default.
• W1969155152 cites W2019098068 @default.
• W1969155152 cites W2019535569 @default.
• W1969155152 cites W2023460725 @default.
• W1969155152 cites W2026021773 @default.
• W1969155152 cites W2027501944 @default.
• W1969155152 cites W2032450628 @default.
• W1969155152 cites W2034876850 @default.
• W1969155152 cites W2042888972 @default.
• W1969155152 cites W2050843442 @default.
• W1969155152 cites W2051346134 @default.
• W1969155152 cites W2057121746 @default.
• W1969155152 cites W2059477899 @default.
• W1969155152 cites W2062170463 @default.
• W1969155152 cites W2064237166 @default.
• W1969155152 cites W2065687261 @default.
• W1969155152 cites W2079641121 @default.
• W1969155152 cites W2083753602 @default.
• W1969155152 cites W2084376330 @default.
• W1969155152 cites W2090183585 @default.
• W1969155152 cites W2093487930 @default.
• W1969155152 cites W2093698034 @default.
• W1969155152 cites W2101464392 @default.
• W1969155152 cites W2102276037 @default.
• W1969155152 cites W2103417372 @default.
• W1969155152 cites W2103949437 @default.
• W1969155152 cites W2106123285 @default.
• W1969155152 cites W2111653865 @default.
• W1969155152 cites W2118094416 @default.
• W1969155152 cites W2140777443 @default.
• W1969155152 cites W2143541324 @default.
• W1969155152 cites W2151034450 @default.
• W1969155152 cites W2152961247 @default.
• W1969155152 cites W2154455081 @default.
• W1969155152 cites W2159145150 @default.
• W1969155152 cites W2162680672 @default.
• W1969155152 cites W2168207172 @default.
• W1969155152 cites W2329427515 @default.
• W1969155152 cites W2416450707 @default.
• W1969155152 cites W2425699490 @default.
• W1969155152 cites W2471094006 @default.
• W1969155152 cites W4255854804 @default.
• W1969155152 cites W4298847896 @default.
• W1969155152 cites W56003192 @default.
• W1969155152 cites W971851131 @default.
• W1969155152 cites W1979716854 @default.
• W1969155152 doi "https://doi.org/10.1128/aac.49.4.1542-1552.2005" @default.
• W1969155152 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1068608" @default.
• W1969155152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15793136" @default.
• W1969155152 hasPublicationYear "2005" @default.
• W1969155152 type Work @default.
• W1969155152 sameAs 1969155152 @default.
• W1969155152 citedByCount "211" @default.
• W1969155152 countsByYear W19691551522012 @default.
• W1969155152 countsByYear W19691551522013 @default.
• W1969155152 countsByYear W19691551522014 @default.
• W1969155152 countsByYear W19691551522015 @default.
• W1969155152 countsByYear W19691551522016 @default.
• W1969155152 countsByYear W19691551522017 @default.
• W1969155152 countsByYear W19691551522018 @default.
• W1969155152 countsByYear W19691551522019 @default.
• W1969155152 countsByYear W19691551522020 @default.
• W1969155152 countsByYear W19691551522021 @default.
• W1969155152 countsByYear W19691551522022 @default.
• W1969155152 countsByYear W19691551522023 @default.
• W1969155152 crossrefType "journal-article" @default.
• W1969155152 hasAuthorship W1969155152A5002640669 @default.

• next