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- W1969156908 endingPage "433" @default.
- W1969156908 startingPage "423" @default.
- W1969156908 abstract "Failure of immunization with the HIV-1 envelope to induce broadly neutralizing antibodies against conserved epitopes is a major barrier to producing a preventive HIV-1 vaccine. Broadly neutralizing monoclonal antibodies (BnAbs) from those subjects who do produce them after years of chronic HIV-1 infection have one or more unusual characteristics, including polyreactivity for host antigens, extensive somatic hypermutation and long, variable heavy-chain third complementarity-determining regions, factors that may limit their expression by host immunoregulatory mechanisms. The isolation of BnAbs from HIV-1–infected subjects and the use of computationally derived clonal lineages as templates provide a new path for HIV-1 vaccine immunogen design. This approach, which should be applicable to many infectious agents, holds promise for the construction of vaccines that can drive B cells along rare but desirable maturation pathways." @default.
- W1969156908 created "2016-06-24" @default.
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- W1969156908 creator A5047959968 @default.
- W1969156908 creator A5051827275 @default.
- W1969156908 creator A5065001474 @default.
- W1969156908 date "2012-05-01" @default.
- W1969156908 modified "2023-10-16" @default.
- W1969156908 title "B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study" @default.
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