Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969156988> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1969156988 endingPage "440" @default.
- W1969156988 startingPage "435" @default.
- W1969156988 abstract "Light has been shown to modulate NMDA receptor function. In this study, we have performed experiments aimed at elucidating the putative site of action of light within the receptor structure. Whole‐cell recordings were performed in Chinese hamster ovary cells expressing various combinations of NMDA receptor subunits. Although there was no apparent difference in the actions of light between wild‐type NR1‐NR2A and NR1‐NR2B subunit configurations, the light enhancement of NMDA‐induced currents was either completely abolished or substantially diminished in the redox site mutants NR1a (C744A, C798A)‐NR2B and NR1a (C744A, C798A)‐NR2A. Further studies demonstrated that chemical reduction of NR1a‐NR2B NMDA receptors decreased its sensitivity to light. In addition, sodium (2‐sulfonatoethyl) methanethiosulfonate (MTSES), used to irreversibly bind free sulfhydryl groups and inactivate the redox site, abolished the effects of light on wild‐type receptors. In contrast, no free sulfhydryls were available for MTSES following light stimulation, suggesting that light itself could not reduce the redox modulatory site. Our results suggest that a functionally intact, oxidized redox site is necessary for light‐induced potentiation. Hence, light and redox modulation of the NMDA receptor may share a common intramolecular pathway for altering the function of this ion channel." @default.
- W1969156988 created "2016-06-24" @default.
- W1969156988 creator A5037025479 @default.
- W1969156988 creator A5049199455 @default.
- W1969156988 date "2002-12-01" @default.
- W1969156988 modified "2023-10-18" @default.
- W1969156988 title "A role for the redox site in the modulation of the NMDA receptor by light" @default.
- W1969156988 cites W1590954967 @default.
- W1969156988 cites W1602481930 @default.
- W1969156988 cites W1868155710 @default.
- W1969156988 cites W1976289522 @default.
- W1969156988 cites W1984430429 @default.
- W1969156988 cites W1984528002 @default.
- W1969156988 cites W1987322407 @default.
- W1969156988 cites W1994522080 @default.
- W1969156988 cites W2007665141 @default.
- W1969156988 cites W2009965529 @default.
- W1969156988 cites W2013348596 @default.
- W1969156988 cites W2018566513 @default.
- W1969156988 cites W2019121351 @default.
- W1969156988 cites W2059777371 @default.
- W1969156988 cites W2064974192 @default.
- W1969156988 cites W2067624239 @default.
- W1969156988 cites W2105278573 @default.
- W1969156988 cites W2110304317 @default.
- W1969156988 cites W2110743602 @default.
- W1969156988 cites W2122023734 @default.
- W1969156988 cites W2140899588 @default.
- W1969156988 cites W2142552401 @default.
- W1969156988 cites W2147734514 @default.
- W1969156988 cites W2169867789 @default.
- W1969156988 cites W4235501979 @default.
- W1969156988 cites W2129932635 @default.
- W1969156988 doi "https://doi.org/10.1113/jphysiol.2002.032755" @default.
- W1969156988 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2290695" @default.
- W1969156988 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12456823" @default.
- W1969156988 hasPublicationYear "2002" @default.
- W1969156988 type Work @default.
- W1969156988 sameAs 1969156988 @default.
- W1969156988 citedByCount "7" @default.
- W1969156988 countsByYear W19691569882013 @default.
- W1969156988 countsByYear W19691569882017 @default.
- W1969156988 countsByYear W19691569882020 @default.
- W1969156988 crossrefType "journal-article" @default.
- W1969156988 hasAuthorship W1969156988A5037025479 @default.
- W1969156988 hasAuthorship W1969156988A5049199455 @default.
- W1969156988 hasBestOaLocation W19691569881 @default.
- W1969156988 hasConcept C12554922 @default.
- W1969156988 hasConcept C170493617 @default.
- W1969156988 hasConcept C178790620 @default.
- W1969156988 hasConcept C185592680 @default.
- W1969156988 hasConcept C55493867 @default.
- W1969156988 hasConcept C55904794 @default.
- W1969156988 hasConcept C67018056 @default.
- W1969156988 hasConcept C86803240 @default.
- W1969156988 hasConceptScore W1969156988C12554922 @default.
- W1969156988 hasConceptScore W1969156988C170493617 @default.
- W1969156988 hasConceptScore W1969156988C178790620 @default.
- W1969156988 hasConceptScore W1969156988C185592680 @default.
- W1969156988 hasConceptScore W1969156988C55493867 @default.
- W1969156988 hasConceptScore W1969156988C55904794 @default.
- W1969156988 hasConceptScore W1969156988C67018056 @default.
- W1969156988 hasConceptScore W1969156988C86803240 @default.
- W1969156988 hasIssue "2" @default.
- W1969156988 hasLocation W19691569881 @default.
- W1969156988 hasLocation W19691569882 @default.
- W1969156988 hasLocation W19691569883 @default.
- W1969156988 hasOpenAccess W1969156988 @default.
- W1969156988 hasPrimaryLocation W19691569881 @default.
- W1969156988 hasRelatedWork W1974893995 @default.
- W1969156988 hasRelatedWork W2021099451 @default.
- W1969156988 hasRelatedWork W2312579622 @default.
- W1969156988 hasRelatedWork W2322840078 @default.
- W1969156988 hasRelatedWork W2408218962 @default.
- W1969156988 hasRelatedWork W2886855338 @default.
- W1969156988 hasRelatedWork W2936188404 @default.
- W1969156988 hasRelatedWork W2952478468 @default.
- W1969156988 hasRelatedWork W4232552561 @default.
- W1969156988 hasRelatedWork W2462484134 @default.
- W1969156988 hasVolume "545" @default.
- W1969156988 isParatext "false" @default.
- W1969156988 isRetracted "false" @default.
- W1969156988 magId "1969156988" @default.
- W1969156988 workType "article" @default.