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• W1969168082 startingPage "348" @default.
• W1969168082 abstract "To evaluate the possibility of using surface molecules as markers for human T helper cell subsets, we studied the expression of surface molecules on T cell clones (TCCs) specific for the major birch pollen allergen, Bet v 1. No difference in the expression of the respective receptors for interferon-γ (IFN-γ), IL-4, IL-6, or IL-10 could be detected on T H subsets, nor did CD25 expression (IL-2R α-chain) differ significantly. However, high expression of CD26 antigen (dipeptidyl peptidase IV) correlated with a T H1/T H0-like phenotype, whereas T H2-like clones displayed a lower expression of CD26 antigen. Comparing cytokine production and CD26 expression simultaneously, we found a correlation between the IL-4/IFN-γ ratio and the density of CD26 per cell. We could show that the amount of IL-4 secretion, and not of IFN-γ secretion, was responsible for this correlation. To evaluate whether CD26 antigen expression is regulated by stimuli inducing a T H1- or T H2-like phenotype, peripheral blood mononuclear cells (PBMC) were cultured in the presence of IL-4, IFN-γ, and IL-12, respectively. Incubation with IL-4 led to T cells with a T H2-like cytokine pattern and a significantly lower expression of CD26; IFN-γ and IL-12 led to a T H1 shift associated with an increased expression of CD26 on CD4+ T cells. By means of intracellular cytokine detection we analyzed expression of CD26 on CD4+ PBMC stimulated to produce IFN-γ or IL-4 on a single cell level. All activated, cytokine-producing CD4+ T cells expressed CD26, but the increase in CD26 expression was higher in cells producing IFN-γ. These data suggest that regulation of CD26 cell surface expression correlates with the production of T H1-like cytokines. (J Allergy Clin Immunol 1997;100:348-55.)" @default.
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• W1969168082 date "1997-09-01" @default.
• W1969168082 modified "2023-10-16" @default.
• W1969168082 title "Cell surface characterization of T lymphocytes and allergen-specific T cell clones: Correlation of CD26 expression with T H1 subsets" @default.
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• W1969168082 doi "https://doi.org/10.1016/s0091-6749(97)70248-3" @default.
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