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• W1969174334 abstract "Interleukin-8 (IL-8), a potent neutrophil chemotactic peptide, has been found in association with human disease, but its contribution to chemotactic activity in humans is not yet known. We asked whether IL-8 is present in inflammatory human pleural effusions, and to what extent it contributes to pleural liquid neutrophil chemotactic activity. Because tumor necrosis factor alpha (TNF-α) is a strong inducer of IL-8, we also asked whether TNF-α was present. For this prospective study, we collected pleural liquid from 51 patients (empyema, 14; parapneumonic, four; tuberculous, eight; malignant, nine; miscellaneous exudative, seven; and transudative, nine), counted pleural neutrophils, and measured IL-8 and TNF-α concentrations in the supernatant. To determine the contribution of IL-8 to chemotactic activity in empyema, we measured the neutrophil migration induced by empyemic liquids before and after addition of anti-IL-8 F(ab′)2 antibody fragments or control anti-IL-6 F(ab′)2 We found that IL-8 concentrations were higher in empyema (61.3 ± 21.0 ng/ml [SEM]) than in all other effusions (1.1 ± 0.5 ng/ml) (p = 0.0001). All empyema liquids had IL-8 concentrations above 2.5 ng/ml, which was true for only three of the other 37 effusions (two parapneumonic, one tuberculous). IL-8 levels correlated with the pleural neutrophil count (r = 0.46; p = 0.007) and the neutrophil chemotactic activity of pleural liquid (r = 0.43; p = 0.008). Anti-IL-8 antibodies decreased chemotactic activity in empyema liquids by 65 ± 5%, whereas the control antibody had no effect (0 ± 5% decrease) (p = 0.0005). Although antigenic TNF-α was found most frequently in empyemic (79% of effusions) and tuberculous (88%) effusions, TNF bioactivity was detected only in empyemic (four of nine effusions), not in tuberculous effusions (zero of seven) (p = 0.044). We conclude that IL-8 represents a major neutrophil chemotactic factor in the pleural liquid of patients with empyema and that intrapleural TNF-α may participate in induction of IL-8 production." @default.
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• W1969174334 date "1992-10-01" @default.
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• W1969174334 title "Interleukin-8 Is a Major Neutrophil Chemotactic Factor in Pleural Liquid of Patients with Empyema" @default.
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• W1969174334 doi "https://doi.org/10.1164/ajrccm/146.4.825" @default.
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