FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969175099> ?p ?o ?g. }

• W1969175099 endingPage "248" @default.
• W1969175099 startingPage "239" @default.
• W1969175099 abstract "Intrauterine growth-restricted (IUGR) offspring are at increased risk of adult obesity, as a result of changes in energy balance mechanisms. We hypothesized that impairment of hypothalamic insulin signaling contributes to hyperphagia in IUGR offspring. Study pregnant dams were 50% food restricted from days 10 to 21 to create IUGR newborns. At 5 weeks of age, food intake was measured following intracerebroventricular (icv) injection of vehicle or insulin (10 mU) in control and IUGR pups. At 6 weeks of age, with pups in fed or fasted (48 h) states, pups received icv vehicle or insulin after which they were decapitated, and hypothalamic arcuate (ARC) nucleus dissected for RNA and protein expression. IUGR rats consumed more food than controls under basal conditions, consistent with upregulated ARC phospho AMP-activated protein kinase (pAMPK) and neuropeptide Y (NPY). Insulin acutely reduced food intake in both control and IUGR rats. Consistent with anorexigenic stimulation, central insulin decreased AMP-activated protein kinase and NPY mRNA expression and increased proopiomelanocortin mRNA expression and pAkt, with significantly reduced responses in IUGR as compared with controls. Despite feeding, IUGR offspring exhibit a persistent state of orexigenic stimulation in the ARC nucleus and relative resistance to the anorexigenic effects of icv insulin. These results suggest that impaired insulin signaling contributes to hyperphagia and obesity in IUGR offspring." @default.
• W1969175099 created "2016-06-24" @default.
• W1969175099 creator A5021572666 @default.
• W1969175099 creator A5044745186 @default.
• W1969175099 creator A5052663328 @default.
• W1969175099 creator A5075730499 @default.
• W1969175099 creator A5075938431 @default.
• W1969175099 creator A5079027515 @default.
• W1969175099 date "2013-02-21" @default.
• W1969175099 modified "2023-10-02" @default.
• W1969175099 title "Mechanism of programmed obesity: altered central insulin sensitivity in growth-restricted juvenile female rats" @default.
• W1969175099 cites W1552295611 @default.
• W1969175099 cites W1561443084 @default.
• W1969175099 cites W1919521423 @default.
• W1969175099 cites W1935135811 @default.
• W1969175099 cites W1963494401 @default.
• W1969175099 cites W1964507136 @default.
• W1969175099 cites W1967915851 @default.
• W1969175099 cites W1968973186 @default.
• W1969175099 cites W1969964748 @default.
• W1969175099 cites W1970123905 @default.
• W1969175099 cites W1970205234 @default.
• W1969175099 cites W1972639286 @default.
• W1969175099 cites W1974564106 @default.
• W1969175099 cites W1975121911 @default.
• W1969175099 cites W1980762122 @default.
• W1969175099 cites W1983730808 @default.
• W1969175099 cites W1994554353 @default.
• W1969175099 cites W2003083236 @default.
• W1969175099 cites W2004325493 @default.
• W1969175099 cites W2018907596 @default.
• W1969175099 cites W2019988911 @default.
• W1969175099 cites W2022884213 @default.
• W1969175099 cites W2025078194 @default.
• W1969175099 cites W2028210682 @default.
• W1969175099 cites W2029998210 @default.
• W1969175099 cites W2031087122 @default.
• W1969175099 cites W2032249126 @default.
• W1969175099 cites W2039597810 @default.
• W1969175099 cites W2041315809 @default.
• W1969175099 cites W2046820832 @default.
• W1969175099 cites W2048264796 @default.
• W1969175099 cites W2054999647 @default.
• W1969175099 cites W2060802533 @default.
• W1969175099 cites W2067066432 @default.
• W1969175099 cites W2071654122 @default.
• W1969175099 cites W2074303577 @default.
• W1969175099 cites W2074874465 @default.
• W1969175099 cites W2078060668 @default.
• W1969175099 cites W2083287902 @default.
• W1969175099 cites W2088777766 @default.
• W1969175099 cites W2099542131 @default.
• W1969175099 cites W2106681373 @default.
• W1969175099 cites W2111509554 @default.
• W1969175099 cites W2114952735 @default.
• W1969175099 cites W2120121824 @default.
• W1969175099 cites W2125089843 @default.
• W1969175099 cites W2126108743 @default.
• W1969175099 cites W2129551022 @default.
• W1969175099 cites W2135550286 @default.
• W1969175099 cites W2135897497 @default.
• W1969175099 cites W2138850858 @default.
• W1969175099 cites W2142924698 @default.
• W1969175099 cites W2143324681 @default.
• W1969175099 cites W2147315135 @default.
• W1969175099 cites W2157675198 @default.
• W1969175099 cites W2159536456 @default.
• W1969175099 cites W2170036922 @default.
• W1969175099 cites W4249375967 @default.
• W1969175099 doi "https://doi.org/10.1017/s2040174413000019" @default.
• W1969175099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25054843" @default.
• W1969175099 hasPublicationYear "2013" @default.
• W1969175099 type Work @default.
• W1969175099 sameAs 1969175099 @default.
• W1969175099 citedByCount "4" @default.
• W1969175099 countsByYear W19691750992015 @default.
• W1969175099 countsByYear W19691750992019 @default.
• W1969175099 countsByYear W19691750992020 @default.
• W1969175099 countsByYear W19691750992022 @default.
• W1969175099 crossrefType "journal-article" @default.
• W1969175099 hasAuthorship W1969175099A5021572666 @default.
• W1969175099 hasAuthorship W1969175099A5044745186 @default.
• W1969175099 hasAuthorship W1969175099A5052663328 @default.
• W1969175099 hasAuthorship W1969175099A5075730499 @default.
• W1969175099 hasAuthorship W1969175099A5075938431 @default.
• W1969175099 hasAuthorship W1969175099A5079027515 @default.
• W1969175099 hasConcept C112446052 @default.
• W1969175099 hasConcept C112672928 @default.
• W1969175099 hasConcept C118303440 @default.
• W1969175099 hasConcept C126322002 @default.
• W1969175099 hasConcept C134018914 @default.
• W1969175099 hasConcept C170493617 @default.
• W1969175099 hasConcept C2524010 @default.
• W1969175099 hasConcept C2777003273 @default.
• W1969175099 hasConcept C2777205416 @default.
• W1969175099 hasConcept C2777391703 @default.
• W1969175099 hasConcept C2778458369 @default.
• W1969175099 hasConcept C2779234561 @default.

• next