Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969183721> ?p ?o ?g. }
- W1969183721 endingPage "470" @default.
- W1969183721 startingPage "464" @default.
- W1969183721 abstract "Novel pyrazole and isoxazole derivatives (6–9) were synthesized as a aromatase inhibitors. Pyrazole was synthesized from hydrazine hydrate and isoxazoles from hydroxylamine hydrochloride under different conditions. Molecular docking studies were carried out for the synthesized compounds. The best score was obtained for the compound (9) followed by compound (6) while compound (8) afforded poorest of the score. Aromatase inhibitory activity for compound (6) having pyrazole ring at 2,3 position showed highest activity followed by nitrile derivative (9). Isomeric forms of isoxazole (7 and 8) showed very poor activity compared to fadrozole and aminoglutethimide. Preliminary kinetic studies have shown that both of the active compounds (6 and 9) are reversible inhibitors of the enzyme." @default.
- W1969183721 created "2016-06-24" @default.
- W1969183721 creator A5009203030 @default.
- W1969183721 creator A5015608341 @default.
- W1969183721 creator A5027757988 @default.
- W1969183721 creator A5039392274 @default.
- W1969183721 creator A5057409261 @default.
- W1969183721 creator A5075469040 @default.
- W1969183721 date "2011-04-01" @default.
- W1969183721 modified "2023-09-23" @default.
- W1969183721 title "Synthesis of some novel androstanes as potential aromatase inhibitors" @default.
- W1969183721 cites W102529405 @default.
- W1969183721 cites W1483986092 @default.
- W1969183721 cites W1848530042 @default.
- W1969183721 cites W1917916477 @default.
- W1969183721 cites W1969967288 @default.
- W1969183721 cites W1971410221 @default.
- W1969183721 cites W1972453896 @default.
- W1969183721 cites W1978203969 @default.
- W1969183721 cites W1980385764 @default.
- W1969183721 cites W1982456961 @default.
- W1969183721 cites W1983471313 @default.
- W1969183721 cites W1984407986 @default.
- W1969183721 cites W1985390824 @default.
- W1969183721 cites W1985588649 @default.
- W1969183721 cites W1996079450 @default.
- W1969183721 cites W1998648500 @default.
- W1969183721 cites W2001116848 @default.
- W1969183721 cites W2005018929 @default.
- W1969183721 cites W2007062193 @default.
- W1969183721 cites W2011705265 @default.
- W1969183721 cites W2015807835 @default.
- W1969183721 cites W2054090476 @default.
- W1969183721 cites W2055131068 @default.
- W1969183721 cites W2074864626 @default.
- W1969183721 cites W2078764279 @default.
- W1969183721 cites W2083631217 @default.
- W1969183721 cites W2090724953 @default.
- W1969183721 cites W2094510597 @default.
- W1969183721 cites W2096202952 @default.
- W1969183721 cites W2114712559 @default.
- W1969183721 cites W2118989803 @default.
- W1969183721 cites W2132040980 @default.
- W1969183721 cites W2142580436 @default.
- W1969183721 cites W2142783428 @default.
- W1969183721 cites W2144896165 @default.
- W1969183721 cites W2156945893 @default.
- W1969183721 cites W2159516503 @default.
- W1969183721 cites W2162403751 @default.
- W1969183721 cites W2165811356 @default.
- W1969183721 cites W2951352205 @default.
- W1969183721 doi "https://doi.org/10.1016/j.steroids.2010.12.013" @default.
- W1969183721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21215765" @default.
- W1969183721 hasPublicationYear "2011" @default.
- W1969183721 type Work @default.
- W1969183721 sameAs 1969183721 @default.
- W1969183721 citedByCount "20" @default.
- W1969183721 countsByYear W19691837212012 @default.
- W1969183721 countsByYear W19691837212013 @default.
- W1969183721 countsByYear W19691837212014 @default.
- W1969183721 countsByYear W19691837212015 @default.
- W1969183721 countsByYear W19691837212016 @default.
- W1969183721 countsByYear W19691837212017 @default.
- W1969183721 countsByYear W19691837212019 @default.
- W1969183721 countsByYear W19691837212020 @default.
- W1969183721 countsByYear W19691837212023 @default.
- W1969183721 crossrefType "journal-article" @default.
- W1969183721 hasAuthorship W1969183721A5009203030 @default.
- W1969183721 hasAuthorship W1969183721A5015608341 @default.
- W1969183721 hasAuthorship W1969183721A5027757988 @default.
- W1969183721 hasAuthorship W1969183721A5039392274 @default.
- W1969183721 hasAuthorship W1969183721A5057409261 @default.
- W1969183721 hasAuthorship W1969183721A5075469040 @default.
- W1969183721 hasConcept C121608353 @default.
- W1969183721 hasConcept C154881586 @default.
- W1969183721 hasConcept C161790260 @default.
- W1969183721 hasConcept C178790620 @default.
- W1969183721 hasConcept C181199279 @default.
- W1969183721 hasConcept C185592680 @default.
- W1969183721 hasConcept C191503008 @default.
- W1969183721 hasConcept C193042331 @default.
- W1969183721 hasConcept C202751555 @default.
- W1969183721 hasConcept C2775976807 @default.
- W1969183721 hasConcept C2775999725 @default.
- W1969183721 hasConcept C2776166826 @default.
- W1969183721 hasConcept C2776597398 @default.
- W1969183721 hasConcept C2777682936 @default.
- W1969183721 hasConcept C2778504769 @default.
- W1969183721 hasConcept C2779240715 @default.
- W1969183721 hasConcept C2781060337 @default.
- W1969183721 hasConcept C2781269603 @default.
- W1969183721 hasConcept C530470458 @default.
- W1969183721 hasConcept C54355233 @default.
- W1969183721 hasConcept C55493867 @default.
- W1969183721 hasConcept C71240020 @default.
- W1969183721 hasConcept C86803240 @default.
- W1969183721 hasConceptScore W1969183721C121608353 @default.
- W1969183721 hasConceptScore W1969183721C154881586 @default.