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• W1969187168 abstract "Abstract The intraperitoneal injection of cadmium chloride (1 mg/kg of the ion) twice a day at 12-hr intervals for a maximum period of 3 days produced a severe inflammatory reaction. This reaction was characterized by an increasing accumulation of the exudate, erythrocytes and inflammatory cells into the peritoneal cavity. The peak leucocyte infiltration appeared to occur in two phases. The first occurred at 48 hr and the second at 96 hr following the initial injection of cadmium. Neutrophils always constituted 48 to 56% of the total leucocytes. Infiltration of other cell types included macrophages, monocytes, lymphocytes, mast cells, eosinophils and basket cells. The cell free supernatant of the peritoneal exudate contained the highest amount of histamine at 24 hr and the lowest amount at 48 hr after the initial injection of cadmium. The supernatant also contained an increasing amount of total PGE2 and PGF2α and total β-glucuronidase and lactic dehydrogenase activity in relation to the time following the initial injection of cadmium. The cyclic nucleotide level in the cell free supernatant of the peritoneal exudate was not significantly altered at the early phase of inflammation. This was however, drastically increased both at 72 and 96 hr following the initial injection. In fact, a 50-fold increase in c-AMP level and 8-fold increase in c-GMP level were noted at 96 hr as compared to their respective levels at 24 hr. The data collected in the present study suggest that the release of histamine, lysosomal enzymes, prostaglandins and cyclic nucleotides are somehow involved in cadmium induced peritonitis in rats." @default.
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• W1969187168 date "1979-06-01" @default.
• W1969187168 modified "2023-10-18" @default.
• W1969187168 title "Biochemical and pathological features of cadmium induced peritonitis in rats" @default.
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• W1969187168 doi "https://doi.org/10.1016/0014-4800(79)90092-3" @default.
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