Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969192215> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W1969192215 endingPage "199" @default.
- W1969192215 startingPage "195" @default.
- W1969192215 abstract "A cytogenetic study was performed on a primary breast carcinoma and its axillary lymph node metastasis from a 53-year-old patient with trisomy 21, a carrier of a constitutional der(21;21). A translocation t(X;21) and the loss of the other X chromosome were shared by all karyotypes from tumor cells. The primary tumor was hyperdiploid with several gains of whole chromosomes. In contrast, most cells from the metastasis shared several rearrangements and losses leading to a hypodiploid karyotype. No normal chromosome 17 was present; instead, an i(17)(q10) and a fragment, detected by chromosome painting and presumably corresponding to a rearranged 17p, were found. Immunostaining for p53 was strongly positive in the metastasis but not in the primary tumor, suggesting a mutation of the TP53 gene in the metastasis. Finally, a small cell population of the metastasis was hyperdiploid like the clone in the primary tumor, suggesting that the node was colonized twice, at an early stage and a later stage of the clonal evolution of the tumor. Genes Chromosom. Cancer 19:195–199, 1997. © 1997 Wiley-Liss Inc." @default.
- W1969192215 created "2016-06-24" @default.
- W1969192215 creator A5007697682 @default.
- W1969192215 creator A5034241900 @default.
- W1969192215 creator A5084210907 @default.
- W1969192215 creator A5084648075 @default.
- W1969192215 date "1997-07-01" @default.
- W1969192215 modified "2023-10-18" @default.
- W1969192215 title "Unusual clonal chromosomal evolution in a breast carcinoma and its lymph node metastasis in a patient with down syndrome" @default.
- W1969192215 cites W103664678 @default.
- W1969192215 cites W1567491324 @default.
- W1969192215 cites W1974386424 @default.
- W1969192215 cites W1974731601 @default.
- W1969192215 cites W2002045822 @default.
- W1969192215 cites W2008029824 @default.
- W1969192215 cites W2028639561 @default.
- W1969192215 cites W2032588002 @default.
- W1969192215 cites W2033453696 @default.
- W1969192215 cites W2048226408 @default.
- W1969192215 doi "https://doi.org/10.1002/(sici)1098-2264(199707)19:3<195::aid-gcc10>3.0.co;2-h" @default.
- W1969192215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9219002" @default.
- W1969192215 hasPublicationYear "1997" @default.
- W1969192215 type Work @default.
- W1969192215 sameAs 1969192215 @default.
- W1969192215 citedByCount "7" @default.
- W1969192215 countsByYear W19691922152014 @default.
- W1969192215 crossrefType "journal-article" @default.
- W1969192215 hasAuthorship W1969192215A5007697682 @default.
- W1969192215 hasAuthorship W1969192215A5034241900 @default.
- W1969192215 hasAuthorship W1969192215A5084210907 @default.
- W1969192215 hasAuthorship W1969192215A5084648075 @default.
- W1969192215 hasConcept C104317684 @default.
- W1969192215 hasConcept C121608353 @default.
- W1969192215 hasConcept C138626823 @default.
- W1969192215 hasConcept C142724271 @default.
- W1969192215 hasConcept C203014093 @default.
- W1969192215 hasConcept C2779013556 @default.
- W1969192215 hasConcept C2780283643 @default.
- W1969192215 hasConcept C2780849966 @default.
- W1969192215 hasConcept C3018521938 @default.
- W1969192215 hasConcept C30481170 @default.
- W1969192215 hasConcept C47924181 @default.
- W1969192215 hasConcept C502942594 @default.
- W1969192215 hasConcept C530470458 @default.
- W1969192215 hasConcept C53226629 @default.
- W1969192215 hasConcept C54355233 @default.
- W1969192215 hasConcept C71924100 @default.
- W1969192215 hasConcept C81089528 @default.
- W1969192215 hasConcept C86803240 @default.
- W1969192215 hasConceptScore W1969192215C104317684 @default.
- W1969192215 hasConceptScore W1969192215C121608353 @default.
- W1969192215 hasConceptScore W1969192215C138626823 @default.
- W1969192215 hasConceptScore W1969192215C142724271 @default.
- W1969192215 hasConceptScore W1969192215C203014093 @default.
- W1969192215 hasConceptScore W1969192215C2779013556 @default.
- W1969192215 hasConceptScore W1969192215C2780283643 @default.
- W1969192215 hasConceptScore W1969192215C2780849966 @default.
- W1969192215 hasConceptScore W1969192215C3018521938 @default.
- W1969192215 hasConceptScore W1969192215C30481170 @default.
- W1969192215 hasConceptScore W1969192215C47924181 @default.
- W1969192215 hasConceptScore W1969192215C502942594 @default.
- W1969192215 hasConceptScore W1969192215C530470458 @default.
- W1969192215 hasConceptScore W1969192215C53226629 @default.
- W1969192215 hasConceptScore W1969192215C54355233 @default.
- W1969192215 hasConceptScore W1969192215C71924100 @default.
- W1969192215 hasConceptScore W1969192215C81089528 @default.
- W1969192215 hasConceptScore W1969192215C86803240 @default.
- W1969192215 hasIssue "3" @default.
- W1969192215 hasLocation W19691922151 @default.
- W1969192215 hasLocation W19691922152 @default.
- W1969192215 hasOpenAccess W1969192215 @default.
- W1969192215 hasPrimaryLocation W19691922151 @default.
- W1969192215 hasRelatedWork W1538548942 @default.
- W1969192215 hasRelatedWork W1974040673 @default.
- W1969192215 hasRelatedWork W1986120104 @default.
- W1969192215 hasRelatedWork W2004201880 @default.
- W1969192215 hasRelatedWork W2013365354 @default.
- W1969192215 hasRelatedWork W2038074792 @default.
- W1969192215 hasRelatedWork W2049947149 @default.
- W1969192215 hasRelatedWork W2091271953 @default.
- W1969192215 hasRelatedWork W2143444317 @default.
- W1969192215 hasRelatedWork W2164171045 @default.
- W1969192215 hasVolume "19" @default.
- W1969192215 isParatext "false" @default.
- W1969192215 isRetracted "false" @default.
- W1969192215 magId "1969192215" @default.
- W1969192215 workType "article" @default.