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- W1969202617 abstract "TNF-related apoptosis-inducing ligand (TRAIL) is a type II integral membrane protein that interacts with multiple receptors and cell types including neurons. In this report, TRAIL protein levels were increased in human monocyte-derived macrophages (MDM) after HIV-1 infection and immune activation. In HIV-1 encephalitic (HIVE) human brain tissue, TRAIL-expressing macrophages were found in association with active caspase-3 positive neurons. Cytotoxic TRAIL receptors 1 and 2 were expressed on neurons in primary human fetal cultures and HIV-1 encephalitic brain tissue. Furthermore, TRAIL induced a dose-dependent effect on neuronal apoptosis. These results support a role for TRAIL in mononuclear phagocyte (MP)-mediated neurotoxicity in HIV-1-associated dementia (HAD)." @default.
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- W1969202617 date "2004-03-01" @default.
- W1969202617 modified "2023-10-11" @default.
- W1969202617 title "TNF-related apoptosis-inducing ligand mediates human neuronal apoptosis: links to HIV-1-associated dementia" @default.
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- W1969202617 doi "https://doi.org/10.1016/j.jneuroim.2003.11.019" @default.
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