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• W1969203528 endingPage "015009" @default.
• W1969203528 startingPage "015009" @default.
• W1969203528 abstract "Scaffolds were fabricated by electrospinning using polycaprolactone (PCL) blended with poly(methyl methacrylate) (PMMA) in ratios of 10/0, 7/3, 5/5 and 3/7. The PCL/PMMA ratio affected the fiber diameter, contact angle, tensile strength and biological in vitro and in vivo properties of the scaffolds, and the 7/3 ratio resulted in a higher mechanical strength than 5/5 and 3/7. In vitro cytotoxicity and proliferation of MG-63 osteoblast cells on these blended scaffolds were examined by MTT assay, and it was found that PCL/PMMA blends are suitable for osteoblast cell proliferation. Confocal images and expression of proliferating cell nuclear antigen confirmed the good proliferation and expression of cells on the 7/3 PCL/PMMA fibrous scaffolds. In vivo bone formation was examined using rat models, and bone formation was observed on the 7/3 PCL/PMMA scaffold within 2 months. In vitro and in vivo results suggest that 7/3 PCL/PMMA scaffolds can be used for bone tissue regeneration." @default.
• W1969203528 created "2016-06-24" @default.
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• W1969203528 date "2013-03-01" @default.
• W1969203528 modified "2023-10-05" @default.
• W1969203528 title "<i>In vitro</i> and <i>in vivo</i> evaluation of electrospun PCL/PMMA fibrous scaffolds for bone regeneration" @default.
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• W1969203528 doi "https://doi.org/10.1088/1468-6996/14/1/015009" @default.
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