FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969207957> ?p ?o ?g. }

• W1969207957 endingPage "1114" @default.
• W1969207957 startingPage "1106" @default.
• W1969207957 abstract "Background. Portal venous (p.v.) peritransplant immunization with dendritic cells from bone marrow cultures, along with cyclosporine (10 mg/kg), produces antigen-specific increased renal allograft survival compared with recipients receiving intravenous (i.v.) immunization. Increased survival is associated with altered cytokine production from recipient T cells restimulated with donor antigen. We used a suppressive subtractive hybridization approach to explore a role in the regulation of transplant rejection for other genes differentially expressed after p.v. immunization. Methods. Subtractive hybridization was performed using tissue from p.v. and i.v. immunized mice and a novel polymerase chain reaction-based approach. A gene-bank search was used to identify the source of the differentially expressed cDNAs. One product, the mouse homologue of rat OX-2, was further analyzed using Western gels and FACS analysis of dendritic cells(NLDC145+) isolated from p.v.-immunized mice. Results. Eighty cDNA clones were obtained by suppressive subtractive hybridization. Differential expression was confirmed in Northern RNA blots. One clone showed sequence homology to a gene encoding a molecule on rat dendritic cells (MRC OX-2), with homology to genes encoding the costimulatory molecules CD80 (B7-1) and CD86 (B7-2). In p.v.-immunized mice, a monoclonal antibody to the rat OX-2 molecule identified, by Western blot analysis, increased expression of a molecule with molecular weight (43 kDa) analagous to rat MRC-OX-2; labels (by FACS analysis) indentified increased numbers of a population of cells staining with NLDC145; and blocks indentified increased graft survival. Conclusion. Our data suggest that OX-2 is functionally important in the increased graft survival seen in p.v.-immunized mice receiving renal allografts." @default.
• W1969207957 created "2016-06-24" @default.
• W1969207957 creator A5013168738 @default.
• W1969207957 creator A5020427179 @default.
• W1969207957 creator A5056472778 @default.
• W1969207957 creator A5072635491 @default.
• W1969207957 date "1998-04-01" @default.
• W1969207957 modified "2023-10-17" @default.
• W1969207957 title "INCREASED EXPRESSION OF THE NOVEL MOLECULE OX-2 IS INVOLVED IN PROLONGATION OF MURINE RENAL ALLOGRAFT SURVIVAL1" @default.
• W1969207957 cites W1966842062 @default.
• W1969207957 cites W1968623335 @default.
• W1969207957 cites W1974136601 @default.
• W1969207957 cites W1983122156 @default.
• W1969207957 cites W1985915533 @default.
• W1969207957 cites W1994227144 @default.
• W1969207957 cites W1995700626 @default.
• W1969207957 cites W1998121841 @default.
• W1969207957 cites W2000133096 @default.
• W1969207957 cites W2000208875 @default.
• W1969207957 cites W2003066349 @default.
• W1969207957 cites W2004212512 @default.
• W1969207957 cites W2008238441 @default.
• W1969207957 cites W2009331647 @default.
• W1969207957 cites W2012617920 @default.
• W1969207957 cites W2016819838 @default.
• W1969207957 cites W2019899829 @default.
• W1969207957 cites W2021685948 @default.
• W1969207957 cites W2023906628 @default.
• W1969207957 cites W2025332550 @default.
• W1969207957 cites W2027590165 @default.
• W1969207957 cites W2030261077 @default.
• W1969207957 cites W2035455050 @default.
• W1969207957 cites W2037626742 @default.
• W1969207957 cites W2045941914 @default.
• W1969207957 cites W2049992406 @default.
• W1969207957 cites W2058091324 @default.
• W1969207957 cites W2059169750 @default.
• W1969207957 cites W2060373504 @default.
• W1969207957 cites W2061624786 @default.
• W1969207957 cites W2068698671 @default.
• W1969207957 cites W2087717265 @default.
• W1969207957 cites W2089467722 @default.
• W1969207957 cites W2092493402 @default.
• W1969207957 cites W2115954882 @default.
• W1969207957 cites W2127463256 @default.
• W1969207957 cites W2140066663 @default.
• W1969207957 cites W2152918507 @default.
• W1969207957 cites W2172466148 @default.
• W1969207957 doi "https://doi.org/10.1097/00007890-199804270-00016" @default.
• W1969207957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9583873" @default.
• W1969207957 hasPublicationYear "1998" @default.
• W1969207957 type Work @default.
• W1969207957 sameAs 1969207957 @default.
• W1969207957 citedByCount "77" @default.
• W1969207957 countsByYear W19692079572012 @default.
• W1969207957 countsByYear W19692079572013 @default.
• W1969207957 countsByYear W19692079572014 @default.
• W1969207957 countsByYear W19692079572016 @default.
• W1969207957 countsByYear W19692079572017 @default.
• W1969207957 countsByYear W19692079572018 @default.
• W1969207957 countsByYear W19692079572021 @default.
• W1969207957 countsByYear W19692079572022 @default.
• W1969207957 crossrefType "journal-article" @default.
• W1969207957 hasAuthorship W1969207957A5013168738 @default.
• W1969207957 hasAuthorship W1969207957A5020427179 @default.
• W1969207957 hasAuthorship W1969207957A5056472778 @default.
• W1969207957 hasAuthorship W1969207957A5072635491 @default.
• W1969207957 hasConcept C104317684 @default.
• W1969207957 hasConcept C147483822 @default.
• W1969207957 hasConcept C153911025 @default.
• W1969207957 hasConcept C154317977 @default.
• W1969207957 hasConcept C177707886 @default.
• W1969207957 hasConcept C187882448 @default.
• W1969207957 hasConcept C189482833 @default.
• W1969207957 hasConcept C196436469 @default.
• W1969207957 hasConcept C202751555 @default.
• W1969207957 hasConcept C203014093 @default.
• W1969207957 hasConcept C2776090121 @default.
• W1969207957 hasConcept C2778297628 @default.
• W1969207957 hasConcept C2781101188 @default.
• W1969207957 hasConcept C39347974 @default.
• W1969207957 hasConcept C54355233 @default.
• W1969207957 hasConcept C81089528 @default.
• W1969207957 hasConcept C86803240 @default.
• W1969207957 hasConcept C8891405 @default.
• W1969207957 hasConceptScore W1969207957C104317684 @default.
• W1969207957 hasConceptScore W1969207957C147483822 @default.
• W1969207957 hasConceptScore W1969207957C153911025 @default.
• W1969207957 hasConceptScore W1969207957C154317977 @default.
• W1969207957 hasConceptScore W1969207957C177707886 @default.
• W1969207957 hasConceptScore W1969207957C187882448 @default.
• W1969207957 hasConceptScore W1969207957C189482833 @default.
• W1969207957 hasConceptScore W1969207957C196436469 @default.
• W1969207957 hasConceptScore W1969207957C202751555 @default.
• W1969207957 hasConceptScore W1969207957C203014093 @default.
• W1969207957 hasConceptScore W1969207957C2776090121 @default.
• W1969207957 hasConceptScore W1969207957C2778297628 @default.
• W1969207957 hasConceptScore W1969207957C2781101188 @default.

• next