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- W1969207966 abstract "Abstract Prothrombin Barcelona is a varient of human prothrombin. Its activation by factor Xa is characterized by two abnormal features. The first one is the absence of one of the two Xa-catalyzed cleavages, and the second one the generation of a thrombin-like activity responsible for the thrombin-catalyzed cleavages on the prothrombin molecule and for the activity toward small substrates but without clotting activity. The molecular species exhibiting the thrombin-like activity have been characterized Diisopropyl phosphofluoridate incorporation experiments show that upon activation, two high molecular weight intermediates bearing an active site are formed: one has the molecular weight of prothrombin, the other of prethrombin 1. In the presence of hirudin, only the first intermediate is formed due to a single cleavage by factor Xa which is therefore responsible for the unmasking of the active site." @default.
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- W1969207966 date "1979-04-01" @default.
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- W1969207966 title "Activation of prothrombin Barcelona evidence for active high molecular weight intermediates" @default.
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- W1969207966 doi "https://doi.org/10.1016/0304-4165(79)90236-8" @default.
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