Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969210306> ?p ?o ?g. }
- W1969210306 endingPage "303" @default.
- W1969210306 startingPage "291" @default.
- W1969210306 abstract "The heart is the first organ to form and function during vertebrate embryogenesis. Using a secreted protein, noggin, which specifically antagonizes bone morphogenetic protein (BMP)-2 and -4, we examined the role played by BMP during the initial myofibrillogenesis in chick cultured precardiac mesoendoderm (mesoderm + endoderm; ME). Conditioned medium from COS7 cells transfected with Xenopus noggin cDNA inhibited the expression of sarcomeric proteins (such as sarcomeric alpha-actinin, Z-line titin, and sarcomeric myosin), and so myofibrillogenesis was perturbed in cultured stage 4 precardiac ME; however, it did not inhibit the expression of smooth muscle alpha-actin (the first isoform of alpha-actin expressed during cardiogenesis). In cultured stage 5 precardiac ME, noggin did not inhibit either the formation of I-Z-I components or the expression of sarcomeric myosin, but it did inhibit the formation of A-bands. Although BMP4 was required to induce expressions of sarcomeric alpha-actinin, titin, and sarcomeric myosin in cultured stage 6 posterolateral mesoderm (noncardiogenic mesoderm), smooth muscle alpha-actin was expressed without the addition of BMP4. Interestingly, in cultured stage 6 posterolateral mesoderm, BMP2 induced the expressions of sarcomeric alpha-actinin and titin, but not of sarcomeric myosin. These results suggest that (1) BMP4 function lies upstream of the initial formation of I-Z-I components and A-bands separately in a stage-dependent manner, and (2) at least two signaling pathways are involved in the initial cardiac myofibrillogenesis: one is an unknown pathway responsible for the expression of smooth muscle alpha-actin; the other is BMP signaling, which is involved in the expression of sarcomeric alpha-actinin, titin, and sarcomeric myosin." @default.
- W1969210306 created "2016-06-24" @default.
- W1969210306 creator A5009549860 @default.
- W1969210306 creator A5012291350 @default.
- W1969210306 creator A5018474648 @default.
- W1969210306 creator A5086343918 @default.
- W1969210306 date "2002-05-01" @default.
- W1969210306 modified "2023-10-12" @default.
- W1969210306 title "Significance of Bone Morphogenetic Protein-4 Function in the Initial Myofibrillogenesis of Chick Cardiogenesis" @default.
- W1969210306 cites W1577509897 @default.
- W1969210306 cites W1827288309 @default.
- W1969210306 cites W1937940610 @default.
- W1969210306 cites W1966082959 @default.
- W1969210306 cites W1975106650 @default.
- W1969210306 cites W1977746306 @default.
- W1969210306 cites W1983130326 @default.
- W1969210306 cites W1984288177 @default.
- W1969210306 cites W1989481002 @default.
- W1969210306 cites W2000290760 @default.
- W1969210306 cites W2012542569 @default.
- W1969210306 cites W2015840464 @default.
- W1969210306 cites W2018044249 @default.
- W1969210306 cites W2019767502 @default.
- W1969210306 cites W2021117664 @default.
- W1969210306 cites W2022598338 @default.
- W1969210306 cites W2023496065 @default.
- W1969210306 cites W2033371172 @default.
- W1969210306 cites W2034318308 @default.
- W1969210306 cites W2036530906 @default.
- W1969210306 cites W2038181873 @default.
- W1969210306 cites W2042249618 @default.
- W1969210306 cites W2043772210 @default.
- W1969210306 cites W2044677343 @default.
- W1969210306 cites W2045026507 @default.
- W1969210306 cites W2046623501 @default.
- W1969210306 cites W2055110202 @default.
- W1969210306 cites W2057249507 @default.
- W1969210306 cites W2058846791 @default.
- W1969210306 cites W2060726822 @default.
- W1969210306 cites W2074404562 @default.
- W1969210306 cites W2076541807 @default.
- W1969210306 cites W2076600697 @default.
- W1969210306 cites W2076787092 @default.
- W1969210306 cites W2077272494 @default.
- W1969210306 cites W2081740469 @default.
- W1969210306 cites W2084503148 @default.
- W1969210306 cites W2085306336 @default.
- W1969210306 cites W2085488253 @default.
- W1969210306 cites W2086067630 @default.
- W1969210306 cites W2088876976 @default.
- W1969210306 cites W2098667096 @default.
- W1969210306 cites W2098983125 @default.
- W1969210306 cites W2101609952 @default.
- W1969210306 cites W2107141327 @default.
- W1969210306 cites W2115798328 @default.
- W1969210306 cites W2119528854 @default.
- W1969210306 cites W2120648798 @default.
- W1969210306 cites W2136907284 @default.
- W1969210306 cites W2140034535 @default.
- W1969210306 cites W2141873651 @default.
- W1969210306 cites W2145844911 @default.
- W1969210306 cites W2146490865 @default.
- W1969210306 cites W2147839272 @default.
- W1969210306 cites W2153339926 @default.
- W1969210306 cites W2159561432 @default.
- W1969210306 cites W2165695219 @default.
- W1969210306 cites W2170202796 @default.
- W1969210306 cites W2170478592 @default.
- W1969210306 cites W2186020965 @default.
- W1969210306 cites W2284225794 @default.
- W1969210306 cites W2318364303 @default.
- W1969210306 cites W2417996544 @default.
- W1969210306 doi "https://doi.org/10.1006/dbio.2002.0637" @default.
- W1969210306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11977982" @default.
- W1969210306 hasPublicationYear "2002" @default.
- W1969210306 type Work @default.
- W1969210306 sameAs 1969210306 @default.
- W1969210306 citedByCount "42" @default.
- W1969210306 countsByYear W19692103062012 @default.
- W1969210306 countsByYear W19692103062013 @default.
- W1969210306 countsByYear W19692103062014 @default.
- W1969210306 countsByYear W19692103062016 @default.
- W1969210306 countsByYear W19692103062021 @default.
- W1969210306 countsByYear W19692103062022 @default.
- W1969210306 countsByYear W19692103062023 @default.
- W1969210306 crossrefType "journal-article" @default.
- W1969210306 hasAuthorship W1969210306A5009549860 @default.
- W1969210306 hasAuthorship W1969210306A5012291350 @default.
- W1969210306 hasAuthorship W1969210306A5018474648 @default.
- W1969210306 hasAuthorship W1969210306A5086343918 @default.
- W1969210306 hasBestOaLocation W19692103061 @default.
- W1969210306 hasConcept C104317684 @default.
- W1969210306 hasConcept C145103041 @default.
- W1969210306 hasConcept C207200792 @default.
- W1969210306 hasConcept C2777164004 @default.
- W1969210306 hasConcept C2778761762 @default.
- W1969210306 hasConcept C2780915607 @default.
- W1969210306 hasConcept C31507581 @default.