FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969216814> ?p ?o ?g. }

• W1969216814 endingPage "145" @default.
• W1969216814 startingPage "138" @default.
• W1969216814 abstract "The rat medial prefrontal cortex is known to have diverse brain functions such as learning and memory, attention, and behavioral flexibility. Although these functions are affected by monoamines (dopamine (DA), noradrenaline (NA) and serotonin (5-HT)) and acetylcholine (ACh), the detailed mechanisms remain unclear. These neuromodulators also have effects on synapse formation and maintenance, and regulate plasticity in the central nervous system (CNS). To clarify the effects of these neuromodulators on changes in the density of synapses in the rat medial prefrontal cortex, we separately administered a D1- or D2-antagonist, NA neurotoxin, 5-HT synthetic inhibitor, or muscarinic ACh antagonist for 1 week, and counted the number of synapses on electron microscopic photographs taken from the prelimbic area of the medial prefrontal cortex. The density of synapses in lamina I was regulated by DA via D1-like receptors, and that in laminae II/III was decreased by depletion of NA or ACh. However, 5-HT did not have a regulatory effect on the synaptic density throughout the layers in this brain region. The data in this study and our previous studies indicate that there are appreciable regional differences in the magnitude of biogenic amine-mediated synaptic plasticity in the rat CNS. These neuromodulators may have a trophic-like effect on the selected neuronal circuit to maintain synaptic contacts in the rat CNS. The synaptic density in the medial prefrontal cortex regulated by monoamines and ACh could be important not only for synaptic plasticity in this region but also for pharmacotherapeutic drug treatment." @default.
• W1969216814 created "2016-06-24" @default.
• W1969216814 creator A5016097790 @default.
• W1969216814 creator A5052992393 @default.
• W1969216814 creator A5087664973 @default.
• W1969216814 date "2004-06-01" @default.
• W1969216814 modified "2023-09-29" @default.
• W1969216814 title "Lamina-selective changes in the density of synapses following perturbation of monoamines and acetylcholine in the rat medial prefrontal cortex" @default.
• W1969216814 cites W1546522923 @default.
• W1969216814 cites W1968813442 @default.
• W1969216814 cites W1978122530 @default.
• W1969216814 cites W1979510857 @default.
• W1969216814 cites W1986673268 @default.
• W1969216814 cites W1989394720 @default.
• W1969216814 cites W1993538553 @default.
• W1969216814 cites W1996287373 @default.
• W1969216814 cites W1998482033 @default.
• W1969216814 cites W2001834798 @default.
• W1969216814 cites W2018027230 @default.
• W1969216814 cites W2019488421 @default.
• W1969216814 cites W2022297536 @default.
• W1969216814 cites W2024405749 @default.
• W1969216814 cites W2028996074 @default.
• W1969216814 cites W2030246136 @default.
• W1969216814 cites W2032609932 @default.
• W1969216814 cites W2039231499 @default.
• W1969216814 cites W2040780324 @default.
• W1969216814 cites W2043555322 @default.
• W1969216814 cites W2070718779 @default.
• W1969216814 cites W2071810655 @default.
• W1969216814 cites W2072209030 @default.
• W1969216814 cites W2073832378 @default.
• W1969216814 cites W2078164585 @default.
• W1969216814 cites W2082378578 @default.
• W1969216814 cites W2089743996 @default.
• W1969216814 cites W2090006102 @default.
• W1969216814 cites W2090685136 @default.
• W1969216814 cites W2094141088 @default.
• W1969216814 cites W2117518771 @default.
• W1969216814 cites W2134257939 @default.
• W1969216814 cites W2144501453 @default.
• W1969216814 cites W2152110038 @default.
• W1969216814 cites W2162545338 @default.
• W1969216814 cites W2403252087 @default.
• W1969216814 cites W993165225 @default.
• W1969216814 doi "https://doi.org/10.1016/j.brainres.2004.03.039" @default.
• W1969216814 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15158170" @default.
• W1969216814 hasPublicationYear "2004" @default.
• W1969216814 type Work @default.
• W1969216814 sameAs 1969216814 @default.
• W1969216814 citedByCount "8" @default.
• W1969216814 countsByYear W19692168142012 @default.
• W1969216814 countsByYear W19692168142017 @default.
• W1969216814 countsByYear W19692168142019 @default.
• W1969216814 countsByYear W19692168142022 @default.
• W1969216814 crossrefType "journal-article" @default.
• W1969216814 hasAuthorship W1969216814A5016097790 @default.
• W1969216814 hasAuthorship W1969216814A5052992393 @default.
• W1969216814 hasAuthorship W1969216814A5087664973 @default.
• W1969216814 hasConcept C112592302 @default.
• W1969216814 hasConcept C127445978 @default.
• W1969216814 hasConcept C134018914 @default.
• W1969216814 hasConcept C148762608 @default.
• W1969216814 hasConcept C169760540 @default.
• W1969216814 hasConcept C169900460 @default.
• W1969216814 hasConcept C170493617 @default.
• W1969216814 hasConcept C17077164 @default.
• W1969216814 hasConcept C174884520 @default.
• W1969216814 hasConcept C185592680 @default.
• W1969216814 hasConcept C187541742 @default.
• W1969216814 hasConcept C187714386 @default.
• W1969216814 hasConcept C2775864247 @default.
• W1969216814 hasConcept C2775910092 @default.
• W1969216814 hasConcept C2781195155 @default.
• W1969216814 hasConcept C513476851 @default.
• W1969216814 hasConcept C55493867 @default.
• W1969216814 hasConcept C86803240 @default.
• W1969216814 hasConcept C98229152 @default.
• W1969216814 hasConceptScore W1969216814C112592302 @default.
• W1969216814 hasConceptScore W1969216814C127445978 @default.
• W1969216814 hasConceptScore W1969216814C134018914 @default.
• W1969216814 hasConceptScore W1969216814C148762608 @default.
• W1969216814 hasConceptScore W1969216814C169760540 @default.
• W1969216814 hasConceptScore W1969216814C169900460 @default.
• W1969216814 hasConceptScore W1969216814C170493617 @default.
• W1969216814 hasConceptScore W1969216814C17077164 @default.
• W1969216814 hasConceptScore W1969216814C174884520 @default.
• W1969216814 hasConceptScore W1969216814C185592680 @default.
• W1969216814 hasConceptScore W1969216814C187541742 @default.
• W1969216814 hasConceptScore W1969216814C187714386 @default.
• W1969216814 hasConceptScore W1969216814C2775864247 @default.
• W1969216814 hasConceptScore W1969216814C2775910092 @default.
• W1969216814 hasConceptScore W1969216814C2781195155 @default.
• W1969216814 hasConceptScore W1969216814C513476851 @default.
• W1969216814 hasConceptScore W1969216814C55493867 @default.
• W1969216814 hasConceptScore W1969216814C86803240 @default.
• W1969216814 hasConceptScore W1969216814C98229152 @default.
• W1969216814 hasFunder F4320320912 @default.

• next