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- W1969216827 abstract "A 52-year-old woman was admitted to the hospital because of hirsutism and virilism which appeared 1 year previously. Pelvic examination did not reveal any ovarian tumor. Endocrinological evaluation showed a highly elevated serum level of testosterone (17.5 nmole/liter). Urinary 17-ketosteroid excretion was normal. At laparotomy a bilateral centrally located ovarian tumor was found which histologically proved to be a Leydig cell tumor. In addition, there was a separate Brenner tumor in the left ovary. Serum concentrations of testosterone, dihydrotestosterone, androstenedione, dehydroepiandrosterone, pregnenolone, progesterone, 17 α -hydroxyprogesterone, and estradiol were measured by a radioimmunoassay in peripheral and ovarian vein blood samples collected at laparotomy and compared to those in a control group of women without any ovarian abnormality. It was found that the Leydig cell tumor secreted large amounts of testosterone but concentrations of the other steroids did not differ significantly from those in the control group." @default.
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- W1969216827 date "1981-04-01" @default.
- W1969216827 modified "2023-10-16" @default.
- W1969216827 title "Steroids in ovarian and peripheral venous blood in a case of ovarian leydig cell tumor" @default.
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- W1969216827 doi "https://doi.org/10.1016/s0090-8258(81)80016-9" @default.
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