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- W1969243089 abstract "Fosmidomycin and FR900098 are inhibitors of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR; IspC), a key enzyme of the mevalonate-independent isoprenoid biosynthesis pathway. We have determined the in-vitro antimalarial activity of two double ester prodrugs 2, 3 in direct comparison with the unmodified FR900098 1 against intraerythrocytic forms of Plasmodium falciparum. Temporarily masking the polar properties of the phosphonate moiety of the DXR inhibitor FR900098 1 enhanced not only its oral bioavailability but also the intrinsic activity of this series against the parasites." @default.
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- W1969243089 date "2007-12-01" @default.
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- W1969243089 title "Double Ester Prodrugs of FR900098 Display EnhancedIn-Vitro Antimalarial Activity" @default.
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- W1969243089 doi "https://doi.org/10.1002/ardp.200700069" @default.
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