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• W1969244079 abstract "Leukotriene biosynthesis inhibitors have potential as new therapeutic agents for asthma and inflammatory diseases. A series of novel substituted 2-cyanoquinolines have been synthesized and the structure activity relationships were evaluated with respect to their ability to inhibit the formation of leukotrienes via the 5-lipoxygenase enzyme. [1S,5R]-2-Cyano-4-(3-furyl)-7-¿3-fluoro-5-[3-(3 alpha-hydroxy-6,8-dioxabicyclo[3.2.1]-octanyl)]phenoxymethyl ¿quinoline (L-746,530) 3 represents a distinct class of inhibitors and possesses in vitro and in vivo potency comparable or superior to naphthalenic analog (L-739,010) 2." @default.
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• W1969244079 date "1998-05-01" @default.
• W1969244079 modified "2023-10-14" @default.
• W1969244079 title "Quinolines as potent 5-lipoxygenase inhibitors: Synthesis and biological profile of L-746,530" @default.
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• W1969244079 doi "https://doi.org/10.1016/s0960-894x(98)00201-7" @default.
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