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- W1969244265 abstract "The Pediatric Vision Scanner (PVS) directly detects strabismus and amblyopia by analyzing binocular scans for the presence or absence of birefringence, which is characteristic of steady, bifoveal fixation. In a preliminary study (AAPOS 2012), the PVS demonstrated 98% sensitivity and 88% specificity. Here we report the sensitivity and specificity for a large cohort, confidence intervals, and analyses of screening errors. 250 children (2-6y) were enrolled; 103 controls and 147 with strabismus and/or amblyopia. In addition to the PVS, children were tested with the SureSight autorefractor and the Randot Preschool Stereoacuity test (RPST). Each test yielded a recommendation of “pass” or “refer.” A comprehensive pediatric ophthalmic examination served as the gold-standard. The PVS correctly identified 144 of 147 children with strabismus and/or amblyopia; sensitivity = 98% (95%CI: 95-100%). The PVS correctly identified 89 of 102 control children; specificity = 87% (95% CI, 79%-96%). The SureSight misclassified 81 children, failing to detect 49 children with strabismus and/or amblyopia and over-referring 18 children with astigmatism. The RPST misclassified 51 children, including similar numbers of affected and control children. Misclassifications were not consistent across tests. Using Bayesian analysis to estimate the performance of each test in a preschool screening setting (assuming a prevalence of 4%), accuracies of 88%, 69%, and 77% were predicted for the PVS, SureSight, and RPST tests, respectively. The PVS identifies children with strabismus and/or amblyopia with high sensitivity, outperforming the SureSight and the RPST. Preschool vision screening may be more efficient with a device that directly detects strabismus and/or amblyopia." @default.
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- W1969244265 date "2013-02-01" @default.
- W1969244265 modified "2023-09-30" @default.
- W1969244265 title "High sensitivity and specificity of the Pediatric Vision Scanner in detecting strabismus and amblyopia in preschool children" @default.
- W1969244265 doi "https://doi.org/10.1016/j.jaapos.2012.12.065" @default.
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