FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W196924667> ?p ?o ?g. }

• W196924667 endingPage "2284" @default.
• W196924667 startingPage "2270" @default.
• W196924667 abstract "Research Article1 May 1996free access Nuclear pore proteins are involved in the biogenesis of functional tRNA. G. Simos G. Simos University of Heidelberg, Institut für Biochemie I, Germany. Search for more papers by this author H. Tekotte H. Tekotte University of Heidelberg, Institut für Biochemie I, Germany. Search for more papers by this author H. Grosjean H. Grosjean University of Heidelberg, Institut für Biochemie I, Germany. Search for more papers by this author A. Segref A. Segref University of Heidelberg, Institut für Biochemie I, Germany. Search for more papers by this author K. Sharma K. Sharma University of Heidelberg, Institut für Biochemie I, Germany. Search for more papers by this author D. Tollervey D. Tollervey University of Heidelberg, Institut für Biochemie I, Germany. Search for more papers by this author E. C. Hurt E. C. Hurt University of Heidelberg, Institut für Biochemie I, Germany. Search for more papers by this author G. Simos G. Simos University of Heidelberg, Institut für Biochemie I, Germany. Search for more papers by this author H. Tekotte H. Tekotte University of Heidelberg, Institut für Biochemie I, Germany. Search for more papers by this author H. Grosjean H. Grosjean University of Heidelberg, Institut für Biochemie I, Germany. Search for more papers by this author A. Segref A. Segref University of Heidelberg, Institut für Biochemie I, Germany. Search for more papers by this author K. Sharma K. Sharma University of Heidelberg, Institut für Biochemie I, Germany. Search for more papers by this author D. Tollervey D. Tollervey University of Heidelberg, Institut für Biochemie I, Germany. Search for more papers by this author E. C. Hurt E. C. Hurt University of Heidelberg, Institut für Biochemie I, Germany. Search for more papers by this author Author Information G. Simos1, H. Tekotte1, H. Grosjean1, A. Segref1, K. Sharma1, D. Tollervey1 and E. C. Hurt1 1University of Heidelberg, Institut für Biochemie I, Germany. The EMBO Journal (1996)15:2270-2284https://doi.org/10.1002/j.1460-2075.1996.tb00580.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Los1p and Pus1p, which are involved in tRNA biogenesis, were found in a genetic screen for components interacting with the nuclear pore protein Nsp1p. LOS1, PUS1 and NSP1 interact functionally, since the combination of mutations in the three genes causes synthetic lethality. Pus1p is an intranuclear protein which exhibits a nucleotide-specific and intron-dependent tRNA pseudouridine synthase activity. Los1p was shown previously to be required for efficient pre-tRNA splicing; we report here that Los1p localizes to the nuclear pores and is linked functionally to several components of the tRNA biogenesis machinery including Pus1p and Tfc4p. When the formation of functional tRNA was analyzed by an in vivo assay, the los1(-) pus1(-) double mutant, as well as several thermosensitive nucleoporin mutants including nsp1, nup116, nup133 and nup85, exhibited loss of suppressor tRNA activity even at permissive temperatures. These data suggest that nuclear pore proteins are required for the biogenesis of functional tRNA. Previous ArticleNext Article Volume 15Issue 91 May 1996In this issue RelatedDetailsLoading ..." @default.
• W196924667 created "2016-06-24" @default.
• W196924667 creator A5011141064 @default.
• W196924667 creator A5019312718 @default.
• W196924667 creator A5041911427 @default.
• W196924667 creator A5047719577 @default.
• W196924667 creator A5057468179 @default.
• W196924667 creator A5073566923 @default.
• W196924667 creator A5073956638 @default.
• W196924667 date "1996-05-01" @default.
• W196924667 modified "2023-09-30" @default.
• W196924667 title "Nuclear pore proteins are involved in the biogenesis of functional tRNA." @default.
• W196924667 cites W101969071 @default.
• W196924667 cites W1446286296 @default.
• W196924667 cites W1490035592 @default.
• W196924667 cites W1497947649 @default.
• W196924667 cites W1504407731 @default.
• W196924667 cites W1515930873 @default.
• W196924667 cites W1538896550 @default.
• W196924667 cites W1556017763 @default.
• W196924667 cites W1562507949 @default.
• W196924667 cites W1597054855 @default.
• W196924667 cites W1643444615 @default.
• W196924667 cites W1821377433 @default.
• W196924667 cites W1844218649 @default.
• W196924667 cites W1904867922 @default.
• W196924667 cites W1963705823 @default.
• W196924667 cites W1975203511 @default.
• W196924667 cites W1987200697 @default.
• W196924667 cites W1989650768 @default.
• W196924667 cites W1994512535 @default.
• W196924667 cites W2007422047 @default.
• W196924667 cites W2008267067 @default.
• W196924667 cites W2008450625 @default.
• W196924667 cites W2008922773 @default.
• W196924667 cites W2012339382 @default.
• W196924667 cites W2012539726 @default.
• W196924667 cites W2013462277 @default.
• W196924667 cites W2019531665 @default.
• W196924667 cites W2020803942 @default.
• W196924667 cites W2028260685 @default.
• W196924667 cites W2029596636 @default.
• W196924667 cites W2031196013 @default.
• W196924667 cites W2032109985 @default.
• W196924667 cites W2038172020 @default.
• W196924667 cites W2047182427 @default.
• W196924667 cites W2047649814 @default.
• W196924667 cites W2051029292 @default.
• W196924667 cites W2054735031 @default.
• W196924667 cites W2058668321 @default.
• W196924667 cites W2060650902 @default.
• W196924667 cites W2060941480 @default.
• W196924667 cites W2064639895 @default.
• W196924667 cites W2064691570 @default.
• W196924667 cites W2067961029 @default.
• W196924667 cites W2085304899 @default.
• W196924667 cites W2093829742 @default.
• W196924667 cites W2099752605 @default.
• W196924667 cites W2102905355 @default.
• W196924667 cites W2105271717 @default.
• W196924667 cites W2124682700 @default.
• W196924667 cites W2138270253 @default.
• W196924667 cites W2144635393 @default.
• W196924667 cites W2154077114 @default.
• W196924667 cites W2167673850 @default.
• W196924667 cites W2171136950 @default.
• W196924667 cites W2171901504 @default.
• W196924667 cites W2180706389 @default.
• W196924667 cites W2210213730 @default.
• W196924667 cites W2286864556 @default.
• W196924667 cites W2404132321 @default.
• W196924667 cites W2416313278 @default.
• W196924667 cites W308604711 @default.
• W196924667 cites W4240065971 @default.
• W196924667 cites W4251106005 @default.
• W196924667 doi "https://doi.org/10.1002/j.1460-2075.1996.tb00580.x" @default.
• W196924667 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/450152" @default.
• W196924667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8641292" @default.
• W196924667 hasPublicationYear "1996" @default.
• W196924667 type Work @default.
• W196924667 sameAs 196924667 @default.
• W196924667 citedByCount "167" @default.
• W196924667 countsByYear W1969246672012 @default.
• W196924667 countsByYear W1969246672013 @default.
• W196924667 countsByYear W1969246672014 @default.
• W196924667 countsByYear W1969246672015 @default.
• W196924667 countsByYear W1969246672016 @default.
• W196924667 countsByYear W1969246672017 @default.
• W196924667 countsByYear W1969246672018 @default.
• W196924667 countsByYear W1969246672019 @default.
• W196924667 countsByYear W1969246672020 @default.
• W196924667 countsByYear W1969246672021 @default.
• W196924667 countsByYear W1969246672022 @default.
• W196924667 countsByYear W1969246672023 @default.
• W196924667 crossrefType "journal-article" @default.
• W196924667 hasAuthorship W196924667A5011141064 @default.
• W196924667 hasAuthorship W196924667A5019312718 @default.
• W196924667 hasAuthorship W196924667A5041911427 @default.

• next