FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969247204> ?p ?o ?g. }

• W1969247204 endingPage "371" @default.
• W1969247204 startingPage "361" @default.
• W1969247204 abstract "mPGES-1 (microsomal prostaglandin E synthase-1) is a stimulus-inducible enzyme that functions downstream of COX (cyclo-oxygenase)-2 in the PGE2 (prostaglandin E2)-biosynthesis pathway. Although COX-2-derived PGE2 is known to play a role in the development of various tumours, the involvement of mPGES-1 in carcinogenesis has not yet been fully understood. In the present study, we used LLC (Lewis lung carcinoma) cells with mPGES-1 knockdown or overexpression, as well as mPGES-1-deficient mice to examine the roles of cancer cell- and host-associated mPGES-1 in the processes of tumorigenesis in vitro and in vivo. We found that siRNA (small interfering RNA) silencing of mPGES-1 in LLC cells decreased PGE2 synthesis markedly, accompanied by reduced cell proliferation, attenuated Matrigel invasiveness and increased extracellular matrix adhesion. Conversely, mPGES-1-overexpressing LLC cells showed increased proliferating and invasive capacities. When implanted subcutaneously into wild-type mice, mPGES-1-silenced cells formed smaller xenograft tumours than did control cells. Furthermore, LLC tumours grafted subcutaneously into mPGES-1-knockout mice grew more slowly than did those grafted into littermate wild-type mice, with concomitant decreases in the density of microvascular networks, the expression of pro-angiogenic vascular endothelial growth factor, and the activity of matrix metalloproteinase-2. Lung metastasis of intravenously injected LLC cells was also significantly less obvious in mPGES-1-null mice than in wild-type mice. Thus our present approaches provide unequivocal evidence for critical roles of the mPGES-1-dependent PGE2 biosynthetic pathway in both cancer cells and host microenvironments in tumour growth and metastasis." @default.
• W1969247204 created "2016-06-24" @default.
• W1969247204 creator A5005363653 @default.
• W1969247204 creator A5014843167 @default.
• W1969247204 creator A5018553332 @default.
• W1969247204 creator A5020729757 @default.
• W1969247204 creator A5030120964 @default.
• W1969247204 creator A5047414438 @default.
• W1969247204 creator A5051593432 @default.
• W1969247204 creator A5052439214 @default.
• W1969247204 creator A5075092495 @default.
• W1969247204 creator A5081522457 @default.
• W1969247204 creator A5086946546 @default.
• W1969247204 date "2009-12-23" @default.
• W1969247204 modified "2023-10-13" @default.
• W1969247204 title "Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis" @default.
• W1969247204 cites W1514189093 @default.
• W1969247204 cites W1869980306 @default.
• W1969247204 cites W1967641836 @default.
• W1969247204 cites W1985804036 @default.
• W1969247204 cites W1991453413 @default.
• W1969247204 cites W1997241564 @default.
• W1969247204 cites W2015930054 @default.
• W1969247204 cites W2022233074 @default.
• W1969247204 cites W2023040133 @default.
• W1969247204 cites W2028129603 @default.
• W1969247204 cites W2031685248 @default.
• W1969247204 cites W2032607036 @default.
• W1969247204 cites W2043707891 @default.
• W1969247204 cites W2062818585 @default.
• W1969247204 cites W2069653953 @default.
• W1969247204 cites W2071716296 @default.
• W1969247204 cites W2073738021 @default.
• W1969247204 cites W2077641423 @default.
• W1969247204 cites W2082140871 @default.
• W1969247204 cites W2083519527 @default.
• W1969247204 cites W2086641174 @default.
• W1969247204 cites W2087744847 @default.
• W1969247204 cites W2103513948 @default.
• W1969247204 cites W2111199059 @default.
• W1969247204 cites W2115340338 @default.
• W1969247204 cites W2119016440 @default.
• W1969247204 cites W2121612337 @default.
• W1969247204 cites W2127558096 @default.
• W1969247204 cites W2127607312 @default.
• W1969247204 cites W2135166720 @default.
• W1969247204 cites W2147330842 @default.
• W1969247204 cites W2148558073 @default.
• W1969247204 cites W2148888228 @default.
• W1969247204 cites W2156924387 @default.
• W1969247204 cites W2158131645 @default.
• W1969247204 cites W2162053625 @default.
• W1969247204 cites W2165011857 @default.
• W1969247204 cites W2165663767 @default.
• W1969247204 cites W2167029659 @default.
• W1969247204 cites W2168051211 @default.
• W1969247204 cites W2330496155 @default.
• W1969247204 doi "https://doi.org/10.1042/bj20090045" @default.
• W1969247204 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2825730" @default.
• W1969247204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19845504" @default.
• W1969247204 hasPublicationYear "2009" @default.
• W1969247204 type Work @default.
• W1969247204 sameAs 1969247204 @default.
• W1969247204 citedByCount "61" @default.
• W1969247204 countsByYear W19692472042012 @default.
• W1969247204 countsByYear W19692472042013 @default.
• W1969247204 countsByYear W19692472042014 @default.
• W1969247204 countsByYear W19692472042015 @default.
• W1969247204 countsByYear W19692472042016 @default.
• W1969247204 countsByYear W19692472042017 @default.
• W1969247204 countsByYear W19692472042018 @default.
• W1969247204 countsByYear W19692472042019 @default.
• W1969247204 countsByYear W19692472042020 @default.
• W1969247204 countsByYear W19692472042022 @default.
• W1969247204 countsByYear W19692472042023 @default.
• W1969247204 crossrefType "journal-article" @default.
• W1969247204 hasAuthorship W1969247204A5005363653 @default.
• W1969247204 hasAuthorship W1969247204A5014843167 @default.
• W1969247204 hasAuthorship W1969247204A5018553332 @default.
• W1969247204 hasAuthorship W1969247204A5020729757 @default.
• W1969247204 hasAuthorship W1969247204A5030120964 @default.
• W1969247204 hasAuthorship W1969247204A5047414438 @default.
• W1969247204 hasAuthorship W1969247204A5051593432 @default.
• W1969247204 hasAuthorship W1969247204A5052439214 @default.
• W1969247204 hasAuthorship W1969247204A5075092495 @default.
• W1969247204 hasAuthorship W1969247204A5081522457 @default.
• W1969247204 hasAuthorship W1969247204A5086946546 @default.
• W1969247204 hasBestOaLocation W19692472041 @default.
• W1969247204 hasConcept C104317684 @default.
• W1969247204 hasConcept C119056186 @default.
• W1969247204 hasConcept C121608353 @default.
• W1969247204 hasConcept C134018914 @default.
• W1969247204 hasConcept C150903083 @default.
• W1969247204 hasConcept C153911025 @default.
• W1969247204 hasConcept C173396325 @default.
• W1969247204 hasConcept C207001950 @default.
• W1969247204 hasConcept C22615655 @default.
• W1969247204 hasConcept C2777198256 @default.

• next