Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969250240> ?p ?o ?g. }
- W1969250240 endingPage "594" @default.
- W1969250240 startingPage "585" @default.
- W1969250240 abstract "Tumor-infiltrating lymphocytes (TIL) were grown from 23 urothelial carcinomas. Phenotyping analysis showed that the TIL cultures were mainly CD3+. Although CD4+ and CD8+ T-cell sub-sets were grown in culture, CD4+ T-cell sub-sets predominated over CD8+ T cells. Immunohistochemical studies performed on 5 tumor specimens confirmed this observation, and indicated that CD4+ T cells surrounded the tumor islets, whereas CD8+ T lymphocytes were localized among the tumor cells. Five short-term carcinoma cell lines established from these urothelial tumors were used as target cells in cytolysis assays in order to investigate the functional anti-tumor activity of autologous TIL. TIL from 4/5 tumors were lytic and 3 TIL lines displayed MHC-class-I-dependent cytotoxicity directed against autologous tumor cells. CD4+ T-cell-depletion experiments performed on TIL line 07 confirmed that CD8+ MHC-class-I-dependent CTL were the predominant effectors. Finally, experiments performed on 6 allogeneic urothelial-cancer cell lines matched for HLA-class-I molecules showed that TIL07 exhibited selective lytic activity toward tumor 07. These data indicate that CD8+ MHC-class-I-dependent CTL present in urothelial carcinomas are functional and may participate in the anti-tumor immune response. Int. J. Cancer 71:585-594, 1997. © 1997 Wiley-Liss, Inc." @default.
- W1969250240 created "2016-06-24" @default.
- W1969250240 creator A5011536902 @default.
- W1969250240 creator A5015955183 @default.
- W1969250240 creator A5016064768 @default.
- W1969250240 creator A5035950631 @default.
- W1969250240 creator A5038609111 @default.
- W1969250240 creator A5039706842 @default.
- W1969250240 creator A5048710140 @default.
- W1969250240 creator A5054231248 @default.
- W1969250240 creator A5054350714 @default.
- W1969250240 creator A5058960823 @default.
- W1969250240 creator A5058971872 @default.
- W1969250240 creator A5062852558 @default.
- W1969250240 creator A5087666393 @default.
- W1969250240 creator A5090660149 @default.
- W1969250240 creator A5090876009 @default.
- W1969250240 date "1997-05-16" @default.
- W1969250240 modified "2023-10-18" @default.
- W1969250240 title "MHC-dependent cytolysis of autologous tumor cells by lymphocytes infiltrating urothelial carcinomas" @default.
- W1969250240 cites W1535342352 @default.
- W1969250240 cites W1570009082 @default.
- W1969250240 cites W1623963004 @default.
- W1969250240 cites W1709508 @default.
- W1969250240 cites W1802347398 @default.
- W1969250240 cites W1890985457 @default.
- W1969250240 cites W1902748641 @default.
- W1969250240 cites W1976639071 @default.
- W1969250240 cites W1981560649 @default.
- W1969250240 cites W1986046751 @default.
- W1969250240 cites W1990389197 @default.
- W1969250240 cites W2001205745 @default.
- W1969250240 cites W2054851015 @default.
- W1969250240 cites W2089600290 @default.
- W1969250240 cites W2089828715 @default.
- W1969250240 cites W2094273481 @default.
- W1969250240 cites W2171762053 @default.
- W1969250240 cites W2333193688 @default.
- W1969250240 cites W2403680576 @default.
- W1969250240 cites W2419351152 @default.
- W1969250240 cites W2460892140 @default.
- W1969250240 cites W3190199274 @default.
- W1969250240 cites W4300765025 @default.
- W1969250240 cites W85108167 @default.
- W1969250240 doi "https://doi.org/10.1002/(sici)1097-0215(19970516)71:4<585::aid-ijc13>3.0.co;2-b" @default.
- W1969250240 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9178812" @default.
- W1969250240 hasPublicationYear "1997" @default.
- W1969250240 type Work @default.
- W1969250240 sameAs 1969250240 @default.
- W1969250240 citedByCount "14" @default.
- W1969250240 countsByYear W19692502402013 @default.
- W1969250240 countsByYear W19692502402016 @default.
- W1969250240 countsByYear W19692502402017 @default.
- W1969250240 countsByYear W19692502402018 @default.
- W1969250240 crossrefType "journal-article" @default.
- W1969250240 hasAuthorship W1969250240A5011536902 @default.
- W1969250240 hasAuthorship W1969250240A5015955183 @default.
- W1969250240 hasAuthorship W1969250240A5016064768 @default.
- W1969250240 hasAuthorship W1969250240A5035950631 @default.
- W1969250240 hasAuthorship W1969250240A5038609111 @default.
- W1969250240 hasAuthorship W1969250240A5039706842 @default.
- W1969250240 hasAuthorship W1969250240A5048710140 @default.
- W1969250240 hasAuthorship W1969250240A5054231248 @default.
- W1969250240 hasAuthorship W1969250240A5054350714 @default.
- W1969250240 hasAuthorship W1969250240A5058960823 @default.
- W1969250240 hasAuthorship W1969250240A5058971872 @default.
- W1969250240 hasAuthorship W1969250240A5062852558 @default.
- W1969250240 hasAuthorship W1969250240A5087666393 @default.
- W1969250240 hasAuthorship W1969250240A5090660149 @default.
- W1969250240 hasAuthorship W1969250240A5090876009 @default.
- W1969250240 hasConcept C147969180 @default.
- W1969250240 hasConcept C154317977 @default.
- W1969250240 hasConcept C167672396 @default.
- W1969250240 hasConcept C170627219 @default.
- W1969250240 hasConcept C202751555 @default.
- W1969250240 hasConcept C203014093 @default.
- W1969250240 hasConcept C207936829 @default.
- W1969250240 hasConcept C2778326572 @default.
- W1969250240 hasConcept C502942594 @default.
- W1969250240 hasConcept C55493867 @default.
- W1969250240 hasConcept C73588182 @default.
- W1969250240 hasConcept C86803240 @default.
- W1969250240 hasConcept C8891405 @default.
- W1969250240 hasConceptScore W1969250240C147969180 @default.
- W1969250240 hasConceptScore W1969250240C154317977 @default.
- W1969250240 hasConceptScore W1969250240C167672396 @default.
- W1969250240 hasConceptScore W1969250240C170627219 @default.
- W1969250240 hasConceptScore W1969250240C202751555 @default.
- W1969250240 hasConceptScore W1969250240C203014093 @default.
- W1969250240 hasConceptScore W1969250240C207936829 @default.
- W1969250240 hasConceptScore W1969250240C2778326572 @default.
- W1969250240 hasConceptScore W1969250240C502942594 @default.
- W1969250240 hasConceptScore W1969250240C55493867 @default.
- W1969250240 hasConceptScore W1969250240C73588182 @default.
- W1969250240 hasConceptScore W1969250240C86803240 @default.
- W1969250240 hasConceptScore W1969250240C8891405 @default.
- W1969250240 hasIssue "4" @default.
- W1969250240 hasLocation W19692502401 @default.