FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969256443> ?p ?o ?g. }

• W1969256443 endingPage "58" @default.
• W1969256443 startingPage "55" @default.
• W1969256443 abstract "Fibroblast growth factor 8 (FGF8), sonic hedgehog (SHH) and nodal signalling pathways play key roles in both development and survival of dopaminergic neurons. Both heterozygous mutations in autosomal recessively inherited Parkinson's disease (PD) genes such as parkin or PINK1 and exposure to exogenous toxins are thought to contribute to the pathogenesis of PD. The aim of our study was to investigate whether heterozygote mutations in fgf8, shh or oep lead to a reduced number of ascending dopaminergic neurons in zebrafish (Danio rerio) or confer increased susceptibility to the PD neurotoxin 1-methyl-4-phenyl-pyridinium (MPP⁺). At 3 days post fertilization, heterozygous mutations in fgf8, shh or oep did not affect the number of ascending dopaminergic neurons, nor did heterozygous mutations in fgf8, shh or oep result in increased susceptibility to MPP⁺. Further work is needed to determine whether haploinsufficiency in other neurodevelopmental genes might confer increased susceptibility to PD-related pathomechanisms." @default.
• W1969256443 created "2016-06-24" @default.
• W1969256443 creator A5026621001 @default.
• W1969256443 creator A5049885731 @default.
• W1969256443 creator A5079625021 @default.
• W1969256443 date "2013-01-01" @default.
• W1969256443 modified "2023-09-23" @default.
• W1969256443 title "Heterozygous mutations in the FGF8, SHH and nodal/transforming growth factor beta pathways do not confer increased dopaminergic neuron vulnerability—A zebrafish study" @default.
• W1969256443 cites W1904387139 @default.
• W1969256443 cites W1971971409 @default.
• W1969256443 cites W1976880781 @default.
• W1969256443 cites W1979163901 @default.
• W1969256443 cites W1984297922 @default.
• W1969256443 cites W200542940 @default.
• W1969256443 cites W2006851801 @default.
• W1969256443 cites W2027115177 @default.
• W1969256443 cites W2047919620 @default.
• W1969256443 cites W2063260002 @default.
• W1969256443 cites W2064858427 @default.
• W1969256443 cites W2067603001 @default.
• W1969256443 cites W2089206347 @default.
• W1969256443 cites W2092283730 @default.
• W1969256443 cites W2093462151 @default.
• W1969256443 cites W2097777783 @default.
• W1969256443 cites W2101024791 @default.
• W1969256443 cites W2115356824 @default.
• W1969256443 cites W2124868173 @default.
• W1969256443 cites W2128281537 @default.
• W1969256443 cites W2133837852 @default.
• W1969256443 cites W2144905520 @default.
• W1969256443 cites W2145036730 @default.
• W1969256443 cites W2145515423 @default.
• W1969256443 cites W2157125891 @default.
• W1969256443 cites W2159534153 @default.
• W1969256443 cites W2165400844 @default.
• W1969256443 cites W2165783038 @default.
• W1969256443 cites W4293875312 @default.
• W1969256443 doi "https://doi.org/10.1016/j.neulet.2012.10.035" @default.
• W1969256443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23123778" @default.
• W1969256443 hasPublicationYear "2013" @default.
• W1969256443 type Work @default.
• W1969256443 sameAs 1969256443 @default.
• W1969256443 citedByCount "1" @default.
• W1969256443 countsByYear W19692564432018 @default.
• W1969256443 crossrefType "journal-article" @default.
• W1969256443 hasAuthorship W1969256443A5026621001 @default.
• W1969256443 hasAuthorship W1969256443A5049885731 @default.
• W1969256443 hasAuthorship W1969256443A5079625021 @default.
• W1969256443 hasConcept C104317684 @default.
• W1969256443 hasConcept C12125453 @default.
• W1969256443 hasConcept C126322002 @default.
• W1969256443 hasConcept C127716648 @default.
• W1969256443 hasConcept C134018914 @default.
• W1969256443 hasConcept C135763542 @default.
• W1969256443 hasConcept C137183658 @default.
• W1969256443 hasConcept C153471976 @default.
• W1969256443 hasConcept C170493617 @default.
• W1969256443 hasConcept C2776094402 @default.
• W1969256443 hasConcept C2776637008 @default.
• W1969256443 hasConcept C2776804853 @default.
• W1969256443 hasConcept C2776878037 @default.
• W1969256443 hasConcept C2777668072 @default.
• W1969256443 hasConcept C2779134260 @default.
• W1969256443 hasConcept C2779734285 @default.
• W1969256443 hasConcept C501734568 @default.
• W1969256443 hasConcept C513476851 @default.
• W1969256443 hasConcept C54355233 @default.
• W1969256443 hasConcept C68838962 @default.
• W1969256443 hasConcept C71924100 @default.
• W1969256443 hasConcept C74373430 @default.
• W1969256443 hasConcept C86803240 @default.
• W1969256443 hasConceptScore W1969256443C104317684 @default.
• W1969256443 hasConceptScore W1969256443C12125453 @default.
• W1969256443 hasConceptScore W1969256443C126322002 @default.
• W1969256443 hasConceptScore W1969256443C127716648 @default.
• W1969256443 hasConceptScore W1969256443C134018914 @default.
• W1969256443 hasConceptScore W1969256443C135763542 @default.
• W1969256443 hasConceptScore W1969256443C137183658 @default.
• W1969256443 hasConceptScore W1969256443C153471976 @default.
• W1969256443 hasConceptScore W1969256443C170493617 @default.
• W1969256443 hasConceptScore W1969256443C2776094402 @default.
• W1969256443 hasConceptScore W1969256443C2776637008 @default.
• W1969256443 hasConceptScore W1969256443C2776804853 @default.
• W1969256443 hasConceptScore W1969256443C2776878037 @default.
• W1969256443 hasConceptScore W1969256443C2777668072 @default.
• W1969256443 hasConceptScore W1969256443C2779134260 @default.
• W1969256443 hasConceptScore W1969256443C2779734285 @default.
• W1969256443 hasConceptScore W1969256443C501734568 @default.
• W1969256443 hasConceptScore W1969256443C513476851 @default.
• W1969256443 hasConceptScore W1969256443C54355233 @default.
• W1969256443 hasConceptScore W1969256443C68838962 @default.
• W1969256443 hasConceptScore W1969256443C71924100 @default.
• W1969256443 hasConceptScore W1969256443C74373430 @default.
• W1969256443 hasConceptScore W1969256443C86803240 @default.
• W1969256443 hasLocation W19692564431 @default.
• W1969256443 hasLocation W19692564432 @default.
• W1969256443 hasOpenAccess W1969256443 @default.
• W1969256443 hasPrimaryLocation W19692564431 @default.

• next