FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969293095> ?p ?o ?g. }

• W1969293095 endingPage "214" @default.
• W1969293095 startingPage "209" @default.
• W1969293095 abstract "External Ca(2+) entry through various Ca(2+)-channel subtypes is responsible for the large oscillations of the cytosolic Ca(2+) concentrations, [Ca(2+)](i), and cell death induced by veratridine in primary cultures of bovine chromaffin cells. Blockade by omega-conotoxin GVIA (GVIA) of N-type Ca(2+) channels, by omega-agatoxin IVA (IVA) of P-type Ca(2+) channels, or by furnidipine of L-type Ca(2+) channels did not afford cytoprotection. However, (omega-conotoxin MVIIC (MVIIC), a wide-spectrum blocker of N-, P- and Q-type Ca(2+) channels greatly protected the cells against the cytotoxic effects of veratridine. Furnidipine further enhanced the cytoprotecting effects of MVIIC. MVIIC but not furuidipine, markedly reduced the oscillations of [Ca(2+)](i) induced by veratridine in single fura-2-loaded chromaffin cells. The results suggest that Ca(2+) entry through any of the different Ca(2+) channel subtypes present in bovine chromaffin cells might be cytotoxic. They also support two ideas: (i) that wide-spectrum neuronal Ca(2+) channel blockers (i.e. MVIIC) might be better cytoprotecting agents than more specific neuronal Ca(2+) channel blockers (i.e., GVIA, IVA, furnidipine); and (ii) that combined Ca(2+) channel blockers may provide greater cytoprotection than single compounds." @default.
• W1969293095 created "2016-06-24" @default.
• W1969293095 creator A5014223206 @default.
• W1969293095 creator A5041984607 @default.
• W1969293095 creator A5054211533 @default.
• W1969293095 creator A5060125681 @default.
• W1969293095 creator A5060565216 @default.
• W1969293095 creator A5070416857 @default.
• W1969293095 date "1996-04-01" @default.
• W1969293095 modified "2023-10-02" @default.
• W1969293095 title "Effects of ω-conotoxin MVIIC on veratridine-induced cytotoxicity and cytosolic Ca2+ oscillations" @default.
• W1969293095 cites W1987283744 @default.
• W1969293095 cites W1987468391 @default.
• W1969293095 cites W1988510192 @default.
• W1969293095 cites W1988844930 @default.
• W1969293095 cites W1995837298 @default.
• W1969293095 cites W2001014315 @default.
• W1969293095 cites W2007514577 @default.
• W1969293095 cites W2019655661 @default.
• W1969293095 cites W2025205996 @default.
• W1969293095 cites W2025573689 @default.
• W1969293095 cites W2029364439 @default.
• W1969293095 cites W2037349520 @default.
• W1969293095 cites W2050717023 @default.
• W1969293095 cites W2057906214 @default.
• W1969293095 cites W2068378623 @default.
• W1969293095 cites W2079700257 @default.
• W1969293095 cites W2093507972 @default.
• W1969293095 cites W2095002112 @default.
• W1969293095 cites W2139539061 @default.
• W1969293095 cites W2141260882 @default.
• W1969293095 cites W2170787296 @default.
• W1969293095 doi "https://doi.org/10.1016/0006-8993(95)01543-4" @default.
• W1969293095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8861627" @default.
• W1969293095 hasPublicationYear "1996" @default.
• W1969293095 type Work @default.
• W1969293095 sameAs 1969293095 @default.
• W1969293095 citedByCount "20" @default.
• W1969293095 countsByYear W19692930952015 @default.
• W1969293095 countsByYear W19692930952016 @default.
• W1969293095 countsByYear W19692930952022 @default.
• W1969293095 crossrefType "journal-article" @default.
• W1969293095 hasAuthorship W1969293095A5014223206 @default.
• W1969293095 hasAuthorship W1969293095A5041984607 @default.
• W1969293095 hasAuthorship W1969293095A5054211533 @default.
• W1969293095 hasAuthorship W1969293095A5060125681 @default.
• W1969293095 hasAuthorship W1969293095A5060565216 @default.
• W1969293095 hasAuthorship W1969293095A5070416857 @default.
• W1969293095 hasConcept C12554922 @default.
• W1969293095 hasConcept C153461711 @default.
• W1969293095 hasConcept C178790620 @default.
• W1969293095 hasConcept C181199279 @default.
• W1969293095 hasConcept C185592680 @default.
• W1969293095 hasConcept C18699975 @default.
• W1969293095 hasConcept C2776986425 @default.
• W1969293095 hasConcept C2778470358 @default.
• W1969293095 hasConcept C30979828 @default.
• W1969293095 hasConcept C50952357 @default.
• W1969293095 hasConcept C519063684 @default.
• W1969293095 hasConcept C537181965 @default.
• W1969293095 hasConcept C55493867 @default.
• W1969293095 hasConcept C85520022 @default.
• W1969293095 hasConcept C86803240 @default.
• W1969293095 hasConcept C98539663 @default.
• W1969293095 hasConceptScore W1969293095C12554922 @default.
• W1969293095 hasConceptScore W1969293095C153461711 @default.
• W1969293095 hasConceptScore W1969293095C178790620 @default.
• W1969293095 hasConceptScore W1969293095C181199279 @default.
• W1969293095 hasConceptScore W1969293095C185592680 @default.
• W1969293095 hasConceptScore W1969293095C18699975 @default.
• W1969293095 hasConceptScore W1969293095C2776986425 @default.
• W1969293095 hasConceptScore W1969293095C2778470358 @default.
• W1969293095 hasConceptScore W1969293095C30979828 @default.
• W1969293095 hasConceptScore W1969293095C50952357 @default.
• W1969293095 hasConceptScore W1969293095C519063684 @default.
• W1969293095 hasConceptScore W1969293095C537181965 @default.
• W1969293095 hasConceptScore W1969293095C55493867 @default.
• W1969293095 hasConceptScore W1969293095C85520022 @default.
• W1969293095 hasConceptScore W1969293095C86803240 @default.
• W1969293095 hasConceptScore W1969293095C98539663 @default.
• W1969293095 hasIssue "1-2" @default.
• W1969293095 hasLocation W19692930951 @default.
• W1969293095 hasLocation W19692930952 @default.
• W1969293095 hasOpenAccess W1969293095 @default.
• W1969293095 hasPrimaryLocation W19692930951 @default.
• W1969293095 hasRelatedWork W1969293095 @default.
• W1969293095 hasRelatedWork W1974594500 @default.
• W1969293095 hasRelatedWork W2004603947 @default.
• W1969293095 hasRelatedWork W2028333614 @default.
• W1969293095 hasRelatedWork W2045160111 @default.
• W1969293095 hasRelatedWork W2047213097 @default.
• W1969293095 hasRelatedWork W2185967238 @default.
• W1969293095 hasRelatedWork W2394712588 @default.
• W1969293095 hasRelatedWork W2408759148 @default.
• W1969293095 hasRelatedWork W2464559427 @default.
• W1969293095 hasVolume "714" @default.
• W1969293095 isParatext "false" @default.
• W1969293095 isRetracted "false" @default.

• next