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- W1969294047 abstract "This meeting is focused on treatment conditions in in vitro testing which, if not adequately controlled, may lead to false positive results. Short-term in vitro testing has contributed immensely to the development of our field of genetic toxicology. At present, however, it seems there is a tendency to attach increasing importance to in vivo results. In this context, I may quote the Guidelines for Mutagenicity Risk Assessment as proposed by EPA (1984). This document states that the Agency will place greater weight on tests conducted in germ cells than in somatic cells, on tests performed in vivo rather than in vitro, in eukaryotes rather than prokaryotes and in mammalian species rather than in submammalian species. In a recent paper, Legator (1986) even goes a step further. Legator states that (I quote): In examining the absolute requirement for in vivo studies, a logical conclusion is that the various tier approaches, suggested for screening are inappropriate. These so called tier approaches generally use simple in vitro systems as an initial screen and then proceed to more complex testing such as in vivo testing. This concept would be workable if our initial screens were overly sensitive, yielding a high percentage of false positives." @default.
- W1969294047 created "2016-06-24" @default.
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- W1969294047 date "1987-09-01" @default.
- W1969294047 modified "2023-09-26" @default.
- W1969294047 title "In vitro testing as a step in the evaluation of in vivo genotoxicity" @default.
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- W1969294047 doi "https://doi.org/10.1016/0165-1218(87)90027-9" @default.
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