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- W1969294083 abstract "The ubiquitin-binding RPN-10 protein serves as a ubiquitin receptor that delivers client proteins to the 26S proteasome. Although ubiquitin recognition is an essential step for proteasomal destruction, deletion of the rpn-10 gene in yeast does not influence viability, indicating redundancy of the substrate delivery pathway. However, their specificity and biological relevance in higher eukaryotes is still enigmatic. We report herein that knockdown of the rpn-10 gene, but not any other proteasome subunit genes, sexually transforms hermaphrodites to females by eliminating hermaphrodite spermatogenesis in Caenorhabditis elegans. The feminization phenotype induced by deletion of the rpn-10 gene was rescued by knockdown of tra-2, one of sexual fate decision genes promoting female development, and its downstream target tra-1, indicating that the TRA-2-mediated sex determination pathway is crucial for the Delta rpn-10-induced sterile phenotype. Intriguingly, we found that co-knockdown of rpn-10 and functionally related ubiquitin ligase ufd-2 overcomes the germline-musculinizing effect of fem-3(gf). Furthermore, TRA-2 proteins accumulated in rpn-10-defective worms. Our results show that the RPN-10-mediated ubiquitin pathway is indispensable for control of the TRA-2-mediated sex-determining pathway." @default.
- W1969294083 created "2016-06-24" @default.
- W1969294083 creator A5025748633 @default.
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- W1969294083 date "2006-12-01" @default.
- W1969294083 modified "2023-10-18" @default.
- W1969294083 title "Proteasomal Ubiquitin Receptor RPN-10 Controls Sex Determination in<i>Caenorhabditis elegans</i>" @default.
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- W1969294083 doi "https://doi.org/10.1091/mbc.e06-05-0437" @default.
- W1969294083 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1687211" @default.
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