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- W1969294269 abstract "A novel metabolic model is formulated to simulate Vero cell growth on glucose in fixed-bed bioreactors by simplification of glucose fluxes in the central carbon metabolism. Model formulation is based on three designated metabolism states: respiratory metabolism, overflow metabolism and critical metabolism. The model is validated by experimental culture results and successfully predicts the dynamics of cell growth, glucose consumption and lactate production. As well as quantitatively describing glucose overflow metabolism in mammalian cell culture, the proposed model will be helpful for directly monitoring and controlling metabolism state of cells in order to achieve process optimization." @default.
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- W1969294269 date "2010-01-01" @default.
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- W1969294269 title "Simple Metabolic Modelling of Vero Cell Growth on Glucose in Fixed-bed Bioreactors" @default.
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- W1969294269 doi "https://doi.org/10.3182/20100707-3-be-2012.0092" @default.
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