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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969296875> ?p ?o ?g. }

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• W1969296875 abstract "RNA interference is a conserved pathway of sequence-specific gene silencing that depends on small guide RNAs and the action of proteins assembled in the RNA-induced silencing complex (RISC). Minimally, the action of RISC requires the endonucleolytic slicer activity of Argonaute2 (Ago2) directed to RNA targets whose sequences are complementary to RISC-incorporated small RNA. To identify RISC components in human cells, we developed an affinity-purification strategy to isolate siRNA-programmed RISC. Here we report the identification of RNA helicase A (RHA) as a human RISC-associated factor. We show that RHA interacts in human cells with siRNA, Ago2, TRBP, and Dicer and functions in the RNAi pathway. In RHA-depleted cells, RNAi was reduced as a consequence of decreased intracellular concentration of active RISC assembled with the guide-strand RNA and Ago2. Our results identify RHA as a RISC component and demonstrate that RHA functions in RISC as an siRNA-loading factor." @default.
• W1969296875 created "2016-06-24" @default.
• W1969296875 creator A5019902933 @default.
• W1969296875 creator A5022854447 @default.
• W1969296875 date "2007-05-01" @default.
• W1969296875 modified "2023-10-14" @default.
• W1969296875 title "RNA Helicase A Interacts with RISC in Human Cells and Functions in RISC Loading" @default.
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• W1969296875 doi "https://doi.org/10.1016/j.molcel.2007.04.016" @default.
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