Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969298311> ?p ?o ?g. }
- W1969298311 endingPage "1185" @default.
- W1969298311 startingPage "1175" @default.
- W1969298311 abstract "Podocytes are highly specialized and terminally differentiated glomerular cells that play a vital role in renal physiology, including the prevention of proteinuria. Cyclin-dependent kinase 5 (CDK5) has been shown to influence several cellular processes in other terminally differentiated cells, in particular neurons. In this study, we examined the role of CDK5 in podocyte differentiation, proliferation, and morphology. In conditionally immortalized mouse podocytes in culture, CDK5 increased in association with podocyte differentiation. During mouse glomerulogenesis in vivo, CDK5 expression was predominantly detected in podocytes from the capillary loop stage to maturation and persisted in the podocytes of adult glomeruli. In contrast, CDK5 was markedly decreased in the proliferating and dedifferentiated podocytes of mice with anti-glomerular basement membrane nephritis and in human immunodeficiency virus transgenic mice. p35, the activator of CDK5, was also detected in podocytes and the p35/CDK5 complex was active. Cell fractionation studies showed that active p35/CDK5 was mainly localized to the plasma membrane. Specific inhibition of CDK5 in differentiated cultured podocytes, either pharmacologically or with siRNA, induced shape changes, with cellular elongation and loss of process formation compared to the characteristic arborized phenotype. These data suggest a role for CDK5 as a regulator of podocyte differentiation, proliferation, and morphology." @default.
- W1969298311 created "2016-06-24" @default.
- W1969298311 creator A5009036785 @default.
- W1969298311 creator A5021412093 @default.
- W1969298311 creator A5028585347 @default.
- W1969298311 creator A5031655398 @default.
- W1969298311 creator A5036956731 @default.
- W1969298311 creator A5042151304 @default.
- W1969298311 creator A5047698585 @default.
- W1969298311 creator A5075527652 @default.
- W1969298311 creator A5076737169 @default.
- W1969298311 date "2004-10-01" @default.
- W1969298311 modified "2023-10-17" @default.
- W1969298311 title "Cyclin-Dependent Kinase 5 Is a Regulator of Podocyte Differentiation, Proliferation, and Morphology" @default.
- W1969298311 cites W1515729616 @default.
- W1969298311 cites W1563116834 @default.
- W1969298311 cites W1637051517 @default.
- W1969298311 cites W1742790777 @default.
- W1969298311 cites W1905265488 @default.
- W1969298311 cites W1971468364 @default.
- W1969298311 cites W1982005004 @default.
- W1969298311 cites W1988171238 @default.
- W1969298311 cites W2001720542 @default.
- W1969298311 cites W2006543103 @default.
- W1969298311 cites W2015595442 @default.
- W1969298311 cites W2021958350 @default.
- W1969298311 cites W2022782470 @default.
- W1969298311 cites W2031800834 @default.
- W1969298311 cites W2033100763 @default.
- W1969298311 cites W2043217551 @default.
- W1969298311 cites W2052352814 @default.
- W1969298311 cites W2064333604 @default.
- W1969298311 cites W2065434206 @default.
- W1969298311 cites W2066394707 @default.
- W1969298311 cites W2073502866 @default.
- W1969298311 cites W2083451944 @default.
- W1969298311 cites W2083455540 @default.
- W1969298311 cites W2095224574 @default.
- W1969298311 cites W2095738067 @default.
- W1969298311 cites W2100990796 @default.
- W1969298311 cites W2134133501 @default.
- W1969298311 cites W2135129680 @default.
- W1969298311 cites W2144508375 @default.
- W1969298311 cites W2144773212 @default.
- W1969298311 cites W2146880144 @default.
- W1969298311 cites W2155641483 @default.
- W1969298311 cites W2168287443 @default.
- W1969298311 cites W2171001136 @default.
- W1969298311 cites W2301131921 @default.
- W1969298311 cites W2414422839 @default.
- W1969298311 doi "https://doi.org/10.1016/s0002-9440(10)63378-0" @default.
- W1969298311 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1618643" @default.
- W1969298311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15466384" @default.
- W1969298311 hasPublicationYear "2004" @default.
- W1969298311 type Work @default.
- W1969298311 sameAs 1969298311 @default.
- W1969298311 citedByCount "60" @default.
- W1969298311 countsByYear W19692983112012 @default.
- W1969298311 countsByYear W19692983112013 @default.
- W1969298311 countsByYear W19692983112014 @default.
- W1969298311 countsByYear W19692983112015 @default.
- W1969298311 countsByYear W19692983112016 @default.
- W1969298311 countsByYear W19692983112017 @default.
- W1969298311 countsByYear W19692983112018 @default.
- W1969298311 countsByYear W19692983112020 @default.
- W1969298311 countsByYear W19692983112021 @default.
- W1969298311 countsByYear W19692983112022 @default.
- W1969298311 countsByYear W19692983112023 @default.
- W1969298311 crossrefType "journal-article" @default.
- W1969298311 hasAuthorship W1969298311A5009036785 @default.
- W1969298311 hasAuthorship W1969298311A5021412093 @default.
- W1969298311 hasAuthorship W1969298311A5028585347 @default.
- W1969298311 hasAuthorship W1969298311A5031655398 @default.
- W1969298311 hasAuthorship W1969298311A5036956731 @default.
- W1969298311 hasAuthorship W1969298311A5042151304 @default.
- W1969298311 hasAuthorship W1969298311A5047698585 @default.
- W1969298311 hasAuthorship W1969298311A5075527652 @default.
- W1969298311 hasAuthorship W1969298311A5076737169 @default.
- W1969298311 hasBestOaLocation W19692983112 @default.
- W1969298311 hasConcept C104317684 @default.
- W1969298311 hasConcept C121738310 @default.
- W1969298311 hasConcept C134018914 @default.
- W1969298311 hasConcept C148738053 @default.
- W1969298311 hasConcept C184235292 @default.
- W1969298311 hasConcept C2777146197 @default.
- W1969298311 hasConcept C2777390665 @default.
- W1969298311 hasConcept C2779561371 @default.
- W1969298311 hasConcept C2780091579 @default.
- W1969298311 hasConcept C55493867 @default.
- W1969298311 hasConcept C62112901 @default.
- W1969298311 hasConcept C82495950 @default.
- W1969298311 hasConcept C86803240 @default.
- W1969298311 hasConcept C95444343 @default.
- W1969298311 hasConcept C97029542 @default.
- W1969298311 hasConceptScore W1969298311C104317684 @default.
- W1969298311 hasConceptScore W1969298311C121738310 @default.
- W1969298311 hasConceptScore W1969298311C134018914 @default.
- W1969298311 hasConceptScore W1969298311C148738053 @default.