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- W1969315096 abstract "Micropuncture study of chronic obstructive nephropathy before and after release of obstruction. The nature of the intrinsic renal defect in chronic obstructive nephropathy was studied in rats with unilateral partial ureteral ligation. In the surface nephrons of chronically hydronephrotic kidneys, proximal intratubular pressure was slightly increased when compared to sham-operated control animals. Tubular fluid flow rate was reduced by 35%, fractional reabsorption was increased by 8% and single nephron filtration rate was 76% of control values. There was no post-obstructive diuresis in rats with a normal contralateral kidney studied 2 to 6 hrs after relief of chronic obstruction and there was no evidence of hyperfiltration or decreased fractional reabsorption in the proximal tubule of surface nephrons in the post-obstructive kidney. A disproportionately high surface nephron to whole kidney glomerular filtration rate (GFR) was present in most animals studied before or after relief of obstruction. It is concluded that the increased fractional excretion of sodium and diminished urine osmolality observed in chronic obstructive nephropathy result from decreased reabsorption in the distal nephron and/or impaired function of the deep nephrons and renal medulla. The results also indicate that these intrarenal functional defects are not solely responsible for the phenomenon of post-obstructive diuresis; it must also depend on other factors such as superimposed volume expansion or further reduction in functioning nephron mass." @default.
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- W1969315096 date "1972-09-01" @default.
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- W1969315096 title "Micropuncture study of chronic obstructive nephropathy before and after release of obstruction" @default.
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- W1969315096 doi "https://doi.org/10.1038/ki.1972.82" @default.
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