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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969331387> ?p ?o ?g. }

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• W1969331387 abstract "The seed storage glycoprotein Arachis hypogaea (Ara h) 1 is a major allergen found in peanuts. The biochemical resistance of food proteins to protease digestion contributes to their allergenicity. The rapid proteolysis of Ara h 1 under gastric conditions challenges this model. Biophysical and in vitro digestion experiments were carried out to identify how Ara h 1 epitopes might survive digestion, despite their facile degradation. The bicupin core of Ara h 1 can be unfolded at low pH and reversibly folded at higher pH. Additionally, peptide fragments from simulated gastric digestion predominantly form noncovalent aggregates when transferred to base. Disulfide cross-links within these aggregates occur as intermediates in relatively low amounts only at early times and play no role in shielding peptides from degradation. It is proposed that peptide fragments which survive gastric conditions form large aggregates in basic environments such as the small intestine, making epitopes available for triggering an allergic response." @default.
• W1969331387 created "2016-06-24" @default.
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• W1969331387 date "2013-08-23" @default.
• W1969331387 modified "2023-09-25" @default.
• W1969331387 title "Evaluating pH-Induced Gastrointestinal Aggregation of Arachis hypogaea 1 Fragments as Potential Components of Peanut Allergy" @default.
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• W1969331387 doi "https://doi.org/10.1021/jf401701t" @default.
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