FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969332557> ?p ?o ?g. }

• W1969332557 endingPage "208" @default.
• W1969332557 startingPage "203" @default.
• W1969332557 abstract "Corrosive esophageal burn is a common health problem in the pediatric age group and causes serious esophageal injuries. The medical treatment in acute phase of corrosive esophageal injury is of particular importance for prevention of esophageal stricture. We therefore aimed to investigate the possible beneficial effect of trapidil (triazolopyrimidine), an inhibitor for phosphodiesterase and platelet-derived-growth-factor, during acute phase of esophageal corrosive injury. Wistar albino rats were randomly allocated to untreated, treated, and sham-operated groups (n = 10 for each group). Corrosive esophageal burn was generated with 10% NaOH solution. The rats were left untreated (untreated group) or treated with trapidil as a single dose of 40 mg/kg intraperitoneally after one hour of the injury (treated group). Abdominal esophageal segment was isolated and tied in sham-control group. The studied esophageal segment was removed from each animal after 24 hours. Malondialdehyde (MDA) and nitric oxide (NO) levels were measured in the esophageal tissues. The ulcer depth was graded by histopathologic examination. MDA and NO levels were significantly higher in the untreated group than in the treated group. Namely, trapidil treatment significantly decreased MDA and NO levels in the injured tissues, the levels of which are similar to those in the tissues of control animals. The grades of ulcer depth were significantly improved in the treated group. These results indicate that the reactive oxygen radicals increase in the early phase of corrosive esophagitis and cause tissue damage. We suggest that trapidil treatment may be useful in acute phase of corrosive esophageal injury." @default.
• W1969332557 created "2016-06-24" @default.
• W1969332557 creator A5016334165 @default.
• W1969332557 creator A5023802757 @default.
• W1969332557 creator A5038074820 @default.
• W1969332557 creator A5045841491 @default.
• W1969332557 creator A5050362830 @default.
• W1969332557 creator A5059582893 @default.
• W1969332557 date "2005-01-01" @default.
• W1969332557 modified "2023-10-16" @default.
• W1969332557 title "Trapidil, an Inhibitor for Phosphodiesterase and Platelet-Derived-Growth Factor, Ameliorates Corrosive Esophageal Burn in Rats" @default.
• W1969332557 cites W1516825695 @default.
• W1969332557 cites W1776133235 @default.
• W1969332557 cites W1965026439 @default.
• W1969332557 cites W1975446968 @default.
• W1969332557 cites W1976956898 @default.
• W1969332557 cites W1982374886 @default.
• W1969332557 cites W1987884450 @default.
• W1969332557 cites W1988441653 @default.
• W1969332557 cites W1989713074 @default.
• W1969332557 cites W1989781718 @default.
• W1969332557 cites W1992712894 @default.
• W1969332557 cites W1993949226 @default.
• W1969332557 cites W2001924523 @default.
• W1969332557 cites W2003997999 @default.
• W1969332557 cites W2028652147 @default.
• W1969332557 cites W2031253418 @default.
• W1969332557 cites W2033562010 @default.
• W1969332557 cites W2045351357 @default.
• W1969332557 cites W2054126728 @default.
• W1969332557 cites W2056076630 @default.
• W1969332557 cites W2083211973 @default.
• W1969332557 cites W2112281566 @default.
• W1969332557 cites W2153915414 @default.
• W1969332557 cites W2177322388 @default.
• W1969332557 cites W2280343259 @default.
• W1969332557 cites W2404244601 @default.
• W1969332557 cites W2411440078 @default.
• W1969332557 cites W3199508213 @default.
• W1969332557 doi "https://doi.org/10.1620/tjem.207.203" @default.
• W1969332557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16210831" @default.
• W1969332557 hasPublicationYear "2005" @default.
• W1969332557 type Work @default.
• W1969332557 sameAs 1969332557 @default.
• W1969332557 citedByCount "10" @default.
• W1969332557 countsByYear W19693325572012 @default.
• W1969332557 countsByYear W19693325572013 @default.
• W1969332557 countsByYear W19693325572016 @default.
• W1969332557 countsByYear W19693325572017 @default.
• W1969332557 countsByYear W19693325572018 @default.
• W1969332557 crossrefType "journal-article" @default.
• W1969332557 hasAuthorship W1969332557A5016334165 @default.
• W1969332557 hasAuthorship W1969332557A5023802757 @default.
• W1969332557 hasAuthorship W1969332557A5038074820 @default.
• W1969332557 hasAuthorship W1969332557A5045841491 @default.
• W1969332557 hasAuthorship W1969332557A5050362830 @default.
• W1969332557 hasAuthorship W1969332557A5059582893 @default.
• W1969332557 hasBestOaLocation W19693325571 @default.
• W1969332557 hasConcept C126322002 @default.
• W1969332557 hasConcept C2776151105 @default.
• W1969332557 hasConcept C2777819096 @default.
• W1969332557 hasConcept C2778401633 @default.
• W1969332557 hasConcept C2779929075 @default.
• W1969332557 hasConcept C2781176595 @default.
• W1969332557 hasConcept C42219234 @default.
• W1969332557 hasConcept C519581460 @default.
• W1969332557 hasConcept C71924100 @default.
• W1969332557 hasConcept C74534348 @default.
• W1969332557 hasConcept C90924648 @default.
• W1969332557 hasConceptScore W1969332557C126322002 @default.
• W1969332557 hasConceptScore W1969332557C2776151105 @default.
• W1969332557 hasConceptScore W1969332557C2777819096 @default.
• W1969332557 hasConceptScore W1969332557C2778401633 @default.
• W1969332557 hasConceptScore W1969332557C2779929075 @default.
• W1969332557 hasConceptScore W1969332557C2781176595 @default.
• W1969332557 hasConceptScore W1969332557C42219234 @default.
• W1969332557 hasConceptScore W1969332557C519581460 @default.
• W1969332557 hasConceptScore W1969332557C71924100 @default.
• W1969332557 hasConceptScore W1969332557C74534348 @default.
• W1969332557 hasConceptScore W1969332557C90924648 @default.
• W1969332557 hasIssue "3" @default.
• W1969332557 hasLocation W19693325571 @default.
• W1969332557 hasLocation W19693325572 @default.
• W1969332557 hasOpenAccess W1969332557 @default.
• W1969332557 hasPrimaryLocation W19693325571 @default.
• W1969332557 hasRelatedWork W2019086812 @default.
• W1969332557 hasRelatedWork W2038656733 @default.
• W1969332557 hasRelatedWork W2056378510 @default.
• W1969332557 hasRelatedWork W2147568679 @default.
• W1969332557 hasRelatedWork W2170431845 @default.
• W1969332557 hasRelatedWork W2347430850 @default.
• W1969332557 hasRelatedWork W2549135832 @default.
• W1969332557 hasRelatedWork W3203171044 @default.
• W1969332557 hasRelatedWork W385057120 @default.
• W1969332557 hasRelatedWork W2184040951 @default.
• W1969332557 hasVolume "207" @default.
• W1969332557 isParatext "false" @default.
• W1969332557 isRetracted "false" @default.

• next