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- W1969346321 abstract "Chemical genetics is an emerging field that takes advantage of combinatorial chemical and small molecule libraries to dissect complex biological processes. Here we establish a fluorescence-based assay to screen for inhibitors of iron uptake by mammalian cells. Using this approach, we screened the National Cancer Institute's Diversity Set library for inhibitors of non-transferrin bound iron uptake. This screen identified 10 novel small molecule inhibitors of iron transport with IC50 values that ranged from 5 to 30 μM. Of these ten compounds, only two blocked uptake of iron mediated by transferrin. Thus, this study characterizes the first small molecule inhibitors that distinguish between different pathways of iron transport." @default.
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- W1969346321 date "2004-03-01" @default.
- W1969346321 modified "2023-10-18" @default.
- W1969346321 title "Identification of Small Molecule Inhibitors that Distinguish between Non-Transferrin Bound Iron Uptake and Transferrin-Mediated Iron Transport" @default.
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- W1969346321 doi "https://doi.org/10.1016/j.chembiol.2004.02.016" @default.
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