Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969348568> ?p ?o ?g. }
- W1969348568 endingPage "893" @default.
- W1969348568 startingPage "879" @default.
- W1969348568 abstract "The ability to evolve is a fundamental feature of biological systems, but the mechanisms underlying this capacity and the evolutionary dynamics of conserved core processes remain elusive. We show that yeast cells deleted of MYO1, encoding the only myosin II normally required for cytokinesis, rapidly evolved divergent pathways to restore growth and cytokinesis. The evolved cytokinesis phenotypes correlated with specific changes in the transcriptome. Polyploidy and aneuploidy were common genetic alterations in the best evolved strains, and aneuploidy could account for gene expression changes due directly to altered chromosome stoichiometry as well as to downstream effects. The phenotypic effect of aneuploidy could be recapitulated with increased copy numbers of specific regulatory genes in myo1Δ cells. These results demonstrate the evolvability of even a well-conserved process and suggest that changes in chromosome stoichiometry provide a source of heritable variation driving the emergence of adaptive phenotypes when the cell division machinery is strongly perturbed." @default.
- W1969348568 created "2016-06-24" @default.
- W1969348568 creator A5004397208 @default.
- W1969348568 creator A5013220996 @default.
- W1969348568 creator A5020602503 @default.
- W1969348568 creator A5026085749 @default.
- W1969348568 creator A5031265292 @default.
- W1969348568 creator A5042275051 @default.
- W1969348568 creator A5050483965 @default.
- W1969348568 creator A5061249827 @default.
- W1969348568 creator A5084255014 @default.
- W1969348568 creator A5085703537 @default.
- W1969348568 date "2008-11-01" @default.
- W1969348568 modified "2023-10-18" @default.
- W1969348568 title "Aneuploidy Underlies Rapid Adaptive Evolution of Yeast Cells Deprived of a Conserved Cytokinesis Motor" @default.
- W1969348568 cites W1530468540 @default.
- W1969348568 cites W1535354154 @default.
- W1969348568 cites W1554180547 @default.
- W1969348568 cites W1641544182 @default.
- W1969348568 cites W1894025839 @default.
- W1969348568 cites W1963674435 @default.
- W1969348568 cites W1967641913 @default.
- W1969348568 cites W1981857633 @default.
- W1969348568 cites W1983811433 @default.
- W1969348568 cites W1996152576 @default.
- W1969348568 cites W1998143618 @default.
- W1969348568 cites W2001795825 @default.
- W1969348568 cites W2006141070 @default.
- W1969348568 cites W2010032067 @default.
- W1969348568 cites W2019234246 @default.
- W1969348568 cites W2030086669 @default.
- W1969348568 cites W2035583578 @default.
- W1969348568 cites W2042699875 @default.
- W1969348568 cites W2044993463 @default.
- W1969348568 cites W2047405437 @default.
- W1969348568 cites W2058616425 @default.
- W1969348568 cites W2063394028 @default.
- W1969348568 cites W2072181411 @default.
- W1969348568 cites W2077941487 @default.
- W1969348568 cites W2080457024 @default.
- W1969348568 cites W2097128462 @default.
- W1969348568 cites W2111209294 @default.
- W1969348568 cites W2112945902 @default.
- W1969348568 cites W2119047826 @default.
- W1969348568 cites W2121411802 @default.
- W1969348568 cites W2128683837 @default.
- W1969348568 cites W2130175477 @default.
- W1969348568 cites W2132919995 @default.
- W1969348568 cites W2157937554 @default.
- W1969348568 cites W2164004777 @default.
- W1969348568 cites W2164832298 @default.
- W1969348568 cites W2166494377 @default.
- W1969348568 cites W2168557059 @default.
- W1969348568 cites W2298630481 @default.
- W1969348568 cites W4211017114 @default.
- W1969348568 cites W4229809574 @default.
- W1969348568 cites W4241088457 @default.
- W1969348568 cites W4247163880 @default.
- W1969348568 doi "https://doi.org/10.1016/j.cell.2008.09.039" @default.
- W1969348568 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2776776" @default.
- W1969348568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19041751" @default.
- W1969348568 hasPublicationYear "2008" @default.
- W1969348568 type Work @default.
- W1969348568 sameAs 1969348568 @default.
- W1969348568 citedByCount "300" @default.
- W1969348568 countsByYear W19693485682012 @default.
- W1969348568 countsByYear W19693485682013 @default.
- W1969348568 countsByYear W19693485682014 @default.
- W1969348568 countsByYear W19693485682015 @default.
- W1969348568 countsByYear W19693485682016 @default.
- W1969348568 countsByYear W19693485682017 @default.
- W1969348568 countsByYear W19693485682018 @default.
- W1969348568 countsByYear W19693485682019 @default.
- W1969348568 countsByYear W19693485682020 @default.
- W1969348568 countsByYear W19693485682021 @default.
- W1969348568 countsByYear W19693485682022 @default.
- W1969348568 countsByYear W19693485682023 @default.
- W1969348568 crossrefType "journal-article" @default.
- W1969348568 hasAuthorship W1969348568A5004397208 @default.
- W1969348568 hasAuthorship W1969348568A5013220996 @default.
- W1969348568 hasAuthorship W1969348568A5020602503 @default.
- W1969348568 hasAuthorship W1969348568A5026085749 @default.
- W1969348568 hasAuthorship W1969348568A5031265292 @default.
- W1969348568 hasAuthorship W1969348568A5042275051 @default.
- W1969348568 hasAuthorship W1969348568A5050483965 @default.
- W1969348568 hasAuthorship W1969348568A5061249827 @default.
- W1969348568 hasAuthorship W1969348568A5084255014 @default.
- W1969348568 hasAuthorship W1969348568A5085703537 @default.
- W1969348568 hasBestOaLocation W19693485681 @default.
- W1969348568 hasConcept C104317684 @default.
- W1969348568 hasConcept C127716648 @default.
- W1969348568 hasConcept C1491633281 @default.
- W1969348568 hasConcept C150194340 @default.
- W1969348568 hasConcept C162317418 @default.
- W1969348568 hasConcept C2778354886 @default.
- W1969348568 hasConcept C2779672484 @default.
- W1969348568 hasConcept C2781011225 @default.
- W1969348568 hasConcept C30481170 @default.