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- W1969353313 abstract "Decreased glomerular proteinase activity may contribute to matrix accumulation in diabetes. Male Sprague-Dawley rats were rendered diabetic by injection of streptozotocin (STZ) 65 mg/kg i.v.; age-matched, sham-injected rats served as controls. Glomeruli from diabetic rats 1 month after STZ injection demonstrated significant decreases in collagenase and cathepsin B activities compared to control glomeruli. Treatment with insulin resulted in a slight (but not significant) increase in collagenase activity and normalized cathepsin B activity. We conclude that decreased glomerular collagenase and cathepsin B activities are present in STZ diabetes. These alterations may contribute to mesangial matrix accumulation." @default.
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- W1969353313 date "1999-01-01" @default.
- W1969353313 modified "2023-10-18" @default.
- W1969353313 title "Decreased Glomerular Proteinase Activity in the Streptozotocin Diabetic Rat" @default.
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- W1969353313 doi "https://doi.org/10.1159/000013492" @default.
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