FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969362293> ?p ?o ?g. }

• W1969362293 endingPage "549" @default.
• W1969362293 startingPage "543" @default.
• W1969362293 abstract "Basic fibroblast growth factor (bFGF), a potent mitogen for arterial smooth muscle cells, has been shown to play a fundamental role in the pathogenesis of arteriosclerosis and restenosis by stimulating the proliferation of vascular smooth muscle cells. We found that partially phosphorothioate-modified 15-residue antisense oligodeoxynucleotides complementary to bFGF mRNA at 0.1–2.0 μM block growth and division of cultured human and bovine coronary smooth muscle cells in a dose-dependent manner. The effect is sequence specific at low (0.1–0.5 μM) nontoxic concentrations. It is associated with inhibition of expression of pericellular and intracellular bFGF, with a decreased de novo synthesis of bFGF and is partly reversible by the addition of exogenous (recombinant) bFGF. The antisense effect lasts 48–72 h and diminishes thereafter. If the antisense oligodeoxynucleotide medium is replaced by an oligo-nucleotide-free medium after 24 h, the [3H]thymidine incorporation rate returns to control levels. Under the same conditions, the corresponding sense oligodeoxynucleotide exerts negligible nonspecific inhibitory actions. The antiproliferative potency of the 15-residue antisense oligodeoxynucleotide is markedly enhanced by adding 3–4 nonbase-pairing guanosine residues at the 5′- and 3′-termini of the 15-residue antisense oligonucleotide. The data implicate bFGF in the process of smooth muscle cell proliferation and an effective and specific antiproliferative potency of bFGF-specific antisense oligonucleotides. The results point to possible new therapeutic strategies for the use of antisense methodology in the suppression of post-angioplasty restenosis." @default.
• W1969362293 created "2016-06-24" @default.
• W1969362293 creator A5009396857 @default.
• W1969362293 creator A5013949359 @default.
• W1969362293 creator A5014814095 @default.
• W1969362293 creator A5016116285 @default.
• W1969362293 creator A5019556596 @default.
• W1969362293 creator A5026735341 @default.
• W1969362293 creator A5032714359 @default.
• W1969362293 creator A5042898209 @default.
• W1969362293 date "1997-09-01" @default.
• W1969362293 modified "2023-09-27" @default.
• W1969362293 title "Sequence-Specific Antiproliferative Effects of Antisense and End-Capping-Modified Antisense Oligodeoxynucleotides Targeted against the 5'-Terminus of Basic-Fibroblast-Growth-Factor mRNA in Coronary Smooth Muscle Cells" @default.
• W1969362293 cites W1487884828 @default.
• W1969362293 cites W1589523033 @default.
• W1969362293 cites W1596577347 @default.
• W1969362293 cites W1672163784 @default.
• W1969362293 cites W1686153396 @default.
• W1969362293 cites W1965632673 @default.
• W1969362293 cites W1968673310 @default.
• W1969362293 cites W2013012232 @default.
• W1969362293 cites W2016696388 @default.
• W1969362293 cites W2032275698 @default.
• W1969362293 cites W2040301098 @default.
• W1969362293 cites W2051189635 @default.
• W1969362293 cites W2060606238 @default.
• W1969362293 cites W2062985950 @default.
• W1969362293 cites W2070684932 @default.
• W1969362293 cites W2074558357 @default.
• W1969362293 cites W2075578776 @default.
• W1969362293 cites W2077506279 @default.
• W1969362293 cites W2080071221 @default.
• W1969362293 cites W2080452080 @default.
• W1969362293 cites W2088145469 @default.
• W1969362293 cites W2094558818 @default.
• W1969362293 cites W2119616229 @default.
• W1969362293 cites W2130075870 @default.
• W1969362293 cites W2137570167 @default.
• W1969362293 cites W2145817021 @default.
• W1969362293 cites W2146354013 @default.
• W1969362293 cites W2153467120 @default.
• W1969362293 cites W2189492442 @default.
• W1969362293 cites W2409470531 @default.
• W1969362293 cites W2411581583 @default.
• W1969362293 cites W4238388249 @default.
• W1969362293 doi "https://doi.org/10.1111/j.1432-1033.1997.00543.x" @default.
• W1969362293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9346314" @default.
• W1969362293 hasPublicationYear "1997" @default.
• W1969362293 type Work @default.
• W1969362293 sameAs 1969362293 @default.
• W1969362293 citedByCount "5" @default.
• W1969362293 crossrefType "journal-article" @default.
• W1969362293 hasAuthorship W1969362293A5009396857 @default.
• W1969362293 hasAuthorship W1969362293A5013949359 @default.
• W1969362293 hasAuthorship W1969362293A5014814095 @default.
• W1969362293 hasAuthorship W1969362293A5016116285 @default.
• W1969362293 hasAuthorship W1969362293A5019556596 @default.
• W1969362293 hasAuthorship W1969362293A5026735341 @default.
• W1969362293 hasAuthorship W1969362293A5032714359 @default.
• W1969362293 hasAuthorship W1969362293A5042898209 @default.
• W1969362293 hasBestOaLocation W19693622931 @default.
• W1969362293 hasConcept C104317684 @default.
• W1969362293 hasConcept C105580179 @default.
• W1969362293 hasConcept C129312508 @default.
• W1969362293 hasConcept C143141573 @default.
• W1969362293 hasConcept C14363569 @default.
• W1969362293 hasConcept C147789679 @default.
• W1969362293 hasConcept C153911025 @default.
• W1969362293 hasConcept C170493617 @default.
• W1969362293 hasConcept C185592680 @default.
• W1969362293 hasConcept C202416437 @default.
• W1969362293 hasConcept C2775960820 @default.
• W1969362293 hasConcept C2777587049 @default.
• W1969362293 hasConcept C2908938912 @default.
• W1969362293 hasConcept C55493867 @default.
• W1969362293 hasConcept C62112901 @default.
• W1969362293 hasConcept C86803240 @default.
• W1969362293 hasConcept C95444343 @default.
• W1969362293 hasConceptScore W1969362293C104317684 @default.
• W1969362293 hasConceptScore W1969362293C105580179 @default.
• W1969362293 hasConceptScore W1969362293C129312508 @default.
• W1969362293 hasConceptScore W1969362293C143141573 @default.
• W1969362293 hasConceptScore W1969362293C14363569 @default.
• W1969362293 hasConceptScore W1969362293C147789679 @default.
• W1969362293 hasConceptScore W1969362293C153911025 @default.
• W1969362293 hasConceptScore W1969362293C170493617 @default.
• W1969362293 hasConceptScore W1969362293C185592680 @default.
• W1969362293 hasConceptScore W1969362293C202416437 @default.
• W1969362293 hasConceptScore W1969362293C2775960820 @default.
• W1969362293 hasConceptScore W1969362293C2777587049 @default.
• W1969362293 hasConceptScore W1969362293C2908938912 @default.
• W1969362293 hasConceptScore W1969362293C55493867 @default.
• W1969362293 hasConceptScore W1969362293C62112901 @default.
• W1969362293 hasConceptScore W1969362293C86803240 @default.
• W1969362293 hasConceptScore W1969362293C95444343 @default.
• W1969362293 hasIssue "2" @default.
• W1969362293 hasLocation W19693622931 @default.
• W1969362293 hasLocation W19693622932 @default.

• next