FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969379635> ?p ?o ?g. }

• W1969379635 endingPage "e20217" @default.
• W1969379635 startingPage "e20217" @default.
• W1969379635 abstract "The induction of sterilizing T-cell responses to tumors is a major goal in the development of T-cell vaccines for treating cancer. Although specific components of anti-viral CD8+ immunity are well characterized, we still lack the ability to mimic viral CD8+ T-cell responses in therapeutic settings for treating cancers. Infection with the picornavirus Theiler's murine encephalomyelitis virus (TMEV) induces a strong sterilizing CD8+ T-cell response. In the absence of sterilizing immunity, the virus causes a persistent infection. We capitalized on the ability of TMEV to induce strong cellular immunity even under conditions of immune deficiency by modifying the virus to evaluate its potential as a T-cell vaccine. The introduction of defined CD8+ T-cell epitopes into the leader sequence of the TMEV genome generates an attenuated vaccine strain that can efficiently drive CD8+ T-cell responses to the targeted antigen. This virus activates T-cells in a manner that is capable of inducing targeted tissue damage and glucose dysregulation in an adoptive T-cell transfer model of diabetes mellitus. As a therapeutic vaccine for the treatment of established melanoma, epitope-modified TMEV can induce strong cytotoxic T-cell responses and promote infiltration of the T-cells into established tumors, ultimately leading to a delay in tumor growth and improved survival of vaccinated animals. We propose that epitope-modified TMEV is an excellent candidate for further development as a human T-cell vaccine for use in immunotherapy." @default.
• W1969379635 created "2016-06-24" @default.
• W1969379635 creator A5026141237 @default.
• W1969379635 creator A5028069544 @default.
• W1969379635 creator A5049868517 @default.
• W1969379635 creator A5050775547 @default.
• W1969379635 creator A5052262813 @default.
• W1969379635 creator A5060051492 @default.
• W1969379635 creator A5060299347 @default.
• W1969379635 creator A5067949341 @default.
• W1969379635 creator A5084751826 @default.
• W1969379635 date "2011-05-20" @default.
• W1969379635 modified "2023-09-23" @default.
• W1969379635 title "Theiler's Murine Encephalomyelitis Virus as a Vaccine Candidate for Immunotherapy" @default.
• W1969379635 cites W1588172428 @default.
• W1969379635 cites W1589138052 @default.
• W1969379635 cites W1590002300 @default.
• W1969379635 cites W1781471553 @default.
• W1969379635 cites W1869309483 @default.
• W1969379635 cites W1926348195 @default.
• W1969379635 cites W1973998328 @default.
• W1969379635 cites W2005463054 @default.
• W1969379635 cites W2011685153 @default.
• W1969379635 cites W2018695684 @default.
• W1969379635 cites W2028996123 @default.
• W1969379635 cites W2039689821 @default.
• W1969379635 cites W2043228528 @default.
• W1969379635 cites W2043648764 @default.
• W1969379635 cites W2056329664 @default.
• W1969379635 cites W2060913542 @default.
• W1969379635 cites W2063706063 @default.
• W1969379635 cites W2065150613 @default.
• W1969379635 cites W2069117077 @default.
• W1969379635 cites W2069166009 @default.
• W1969379635 cites W2086286519 @default.
• W1969379635 cites W2092055002 @default.
• W1969379635 cites W2092905994 @default.
• W1969379635 cites W2093860288 @default.
• W1969379635 cites W2115081562 @default.
• W1969379635 cites W2115181366 @default.
• W1969379635 cites W2137758919 @default.
• W1969379635 cites W2138627134 @default.
• W1969379635 cites W2140060754 @default.
• W1969379635 cites W2146058076 @default.
• W1969379635 cites W2148630237 @default.
• W1969379635 cites W2150491428 @default.
• W1969379635 cites W2152578495 @default.
• W1969379635 cites W2157252414 @default.
• W1969379635 cites W2162074059 @default.
• W1969379635 cites W2166495301 @default.
• W1969379635 cites W2171030678 @default.
• W1969379635 cites W4232309504 @default.
• W1969379635 doi "https://doi.org/10.1371/journal.pone.0020217" @default.
• W1969379635 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3098865" @default.
• W1969379635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21625449" @default.
• W1969379635 hasPublicationYear "2011" @default.
• W1969379635 type Work @default.
• W1969379635 sameAs 1969379635 @default.
• W1969379635 citedByCount "24" @default.
• W1969379635 countsByYear W19693796352012 @default.
• W1969379635 countsByYear W19693796352013 @default.
• W1969379635 countsByYear W19693796352014 @default.
• W1969379635 countsByYear W19693796352015 @default.
• W1969379635 countsByYear W19693796352016 @default.
• W1969379635 countsByYear W19693796352017 @default.
• W1969379635 countsByYear W19693796352018 @default.
• W1969379635 countsByYear W19693796352019 @default.
• W1969379635 countsByYear W19693796352020 @default.
• W1969379635 countsByYear W19693796352021 @default.
• W1969379635 countsByYear W19693796352022 @default.
• W1969379635 crossrefType "journal-article" @default.
• W1969379635 hasAuthorship W1969379635A5026141237 @default.
• W1969379635 hasAuthorship W1969379635A5028069544 @default.
• W1969379635 hasAuthorship W1969379635A5049868517 @default.
• W1969379635 hasAuthorship W1969379635A5050775547 @default.
• W1969379635 hasAuthorship W1969379635A5052262813 @default.
• W1969379635 hasAuthorship W1969379635A5060051492 @default.
• W1969379635 hasAuthorship W1969379635A5060299347 @default.
• W1969379635 hasAuthorship W1969379635A5067949341 @default.
• W1969379635 hasAuthorship W1969379635A5084751826 @default.
• W1969379635 hasBestOaLocation W19693796351 @default.
• W1969379635 hasConcept C147483822 @default.
• W1969379635 hasConcept C154317977 @default.
• W1969379635 hasConcept C159047783 @default.
• W1969379635 hasConcept C167672396 @default.
• W1969379635 hasConcept C195616568 @default.
• W1969379635 hasConcept C202751555 @default.
• W1969379635 hasConcept C203014093 @default.
• W1969379635 hasConcept C2522874641 @default.
• W1969379635 hasConcept C2776090121 @default.
• W1969379635 hasConcept C2777701055 @default.
• W1969379635 hasConcept C2779341262 @default.
• W1969379635 hasConcept C55493867 @default.
• W1969379635 hasConcept C86803240 @default.
• W1969379635 hasConcept C8891405 @default.
• W1969379635 hasConcept C90375314 @default.
• W1969379635 hasConceptScore W1969379635C147483822 @default.
• W1969379635 hasConceptScore W1969379635C154317977 @default.

• next