FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969383564> ?p ?o ?g. }

• W1969383564 endingPage "e35711" @default.
• W1969383564 startingPage "e35711" @default.
• W1969383564 abstract "Purpose Patients with neurofibromatosis 1 (NF1), NF2, and schwannomatosis are at risk for multiple nerve sheath tumors and premature mortality. Traditional magnetic resonance imaging (MRI) has limited ability to assess disease burden accurately. The aim of this study was to establish an international cohort of patients with quantified whole-body internal tumor burden and to correlate tumor burden with clinical features of disease. Methods We determined the number, volume, and distribution of internal nerve sheath tumors in patients using whole-body MRI (WBMRI) and three-dimensional computerized volumetry. We quantified the distribution of tumor volume across body regions and used unsupervised cluster analysis to group patients based on tumor distribution. We correlated the presence and volume of internal tumors with disease-related and demographic factors. Results WBMRI identified 1286 tumors in 145/247 patients (59%). Schwannomatosis patients had the highest prevalence of tumors (P = 0.03), but NF1 patients had the highest median tumor volume (P = 0.02). Tumor volume was unevenly distributed across body regions with overrepresentation of the head/neck and pelvis. Risk factors for internal nerve sheath tumors included decreasing numbers of café-au-lait macules in NF1 patients (P = 0.003) and history of skeletal abnormalities in NF2 patients (P = 0.09). Risk factors for higher tumor volume included female gender (P = 0.05) and increasing subcutaneous neurofibromas (P = 0.03) in NF1 patients, absence of cutaneous schwannomas in NF2 patients (P = 0.06), and increasing age in schwannomatosis patients (p = 0.10). Conclusion WBMRI provides a comprehensive phenotype of neurofibromatosis patients, identifies distinct anatomic subgroups, and provides the basis for investigating molecular biomarkers that correlate with unique disease manifestations." @default.
• W1969383564 created "2016-06-24" @default.
• W1969383564 creator A5013091949 @default.
• W1969383564 creator A5015043044 @default.
• W1969383564 creator A5033017301 @default.
• W1969383564 creator A5036154152 @default.
• W1969383564 creator A5046207137 @default.
• W1969383564 creator A5057867367 @default.
• W1969383564 creator A5059200813 @default.
• W1969383564 creator A5059797681 @default.
• W1969383564 creator A5061307417 @default.
• W1969383564 creator A5071492308 @default.
• W1969383564 creator A5071899499 @default.
• W1969383564 creator A5078317789 @default.
• W1969383564 creator A5081095608 @default.
• W1969383564 date "2012-04-27" @default.
• W1969383564 modified "2023-09-26" @default.
• W1969383564 title "Quantitative Assessment of Whole-Body Tumor Burden in Adult Patients with Neurofibromatosis" @default.
• W1969383564 cites W1952508659 @default.
• W1969383564 cites W1984877682 @default.
• W1969383564 cites W1985094328 @default.
• W1969383564 cites W2000690172 @default.
• W1969383564 cites W2000980908 @default.
• W1969383564 cites W2008471038 @default.
• W1969383564 cites W2012897956 @default.
• W1969383564 cites W2014159406 @default.
• W1969383564 cites W2017444651 @default.
• W1969383564 cites W2025568716 @default.
• W1969383564 cites W2026686051 @default.
• W1969383564 cites W2029976610 @default.
• W1969383564 cites W2044976670 @default.
• W1969383564 cites W2048643924 @default.
• W1969383564 cites W2059852545 @default.
• W1969383564 cites W2069855539 @default.
• W1969383564 cites W2070983123 @default.
• W1969383564 cites W2071485453 @default.
• W1969383564 cites W2085792148 @default.
• W1969383564 cites W2086610618 @default.
• W1969383564 cites W2119477678 @default.
• W1969383564 cites W2128140173 @default.
• W1969383564 cites W2130848213 @default.
• W1969383564 cites W2138616826 @default.
• W1969383564 cites W2143617564 @default.
• W1969383564 cites W2146326641 @default.
• W1969383564 cites W2150706412 @default.
• W1969383564 cites W2162168023 @default.
• W1969383564 cites W2165972341 @default.
• W1969383564 cites W2170946947 @default.
• W1969383564 cites W3124903582 @default.
• W1969383564 doi "https://doi.org/10.1371/journal.pone.0035711" @default.
• W1969383564 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3338705" @default.
• W1969383564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22558206" @default.
• W1969383564 hasPublicationYear "2012" @default.
• W1969383564 type Work @default.
• W1969383564 sameAs 1969383564 @default.
• W1969383564 citedByCount "123" @default.
• W1969383564 countsByYear W19693835642012 @default.
• W1969383564 countsByYear W19693835642013 @default.
• W1969383564 countsByYear W19693835642014 @default.
• W1969383564 countsByYear W19693835642015 @default.
• W1969383564 countsByYear W19693835642016 @default.
• W1969383564 countsByYear W19693835642017 @default.
• W1969383564 countsByYear W19693835642018 @default.
• W1969383564 countsByYear W19693835642019 @default.
• W1969383564 countsByYear W19693835642020 @default.
• W1969383564 countsByYear W19693835642021 @default.
• W1969383564 countsByYear W19693835642022 @default.
• W1969383564 countsByYear W19693835642023 @default.
• W1969383564 crossrefType "journal-article" @default.
• W1969383564 hasAuthorship W1969383564A5013091949 @default.
• W1969383564 hasAuthorship W1969383564A5015043044 @default.
• W1969383564 hasAuthorship W1969383564A5033017301 @default.
• W1969383564 hasAuthorship W1969383564A5036154152 @default.
• W1969383564 hasAuthorship W1969383564A5046207137 @default.
• W1969383564 hasAuthorship W1969383564A5057867367 @default.
• W1969383564 hasAuthorship W1969383564A5059200813 @default.
• W1969383564 hasAuthorship W1969383564A5059797681 @default.
• W1969383564 hasAuthorship W1969383564A5061307417 @default.
• W1969383564 hasAuthorship W1969383564A5071492308 @default.
• W1969383564 hasAuthorship W1969383564A5071899499 @default.
• W1969383564 hasAuthorship W1969383564A5078317789 @default.
• W1969383564 hasAuthorship W1969383564A5081095608 @default.
• W1969383564 hasBestOaLocation W19693835641 @default.
• W1969383564 hasConcept C126838900 @default.
• W1969383564 hasConcept C142724271 @default.
• W1969383564 hasConcept C143409427 @default.
• W1969383564 hasConcept C2777831590 @default.
• W1969383564 hasConcept C2778173781 @default.
• W1969383564 hasConcept C2778357063 @default.
• W1969383564 hasConcept C2778984943 @default.
• W1969383564 hasConcept C2778986146 @default.
• W1969383564 hasConcept C2781447767 @default.
• W1969383564 hasConcept C71924100 @default.
• W1969383564 hasConceptScore W1969383564C126838900 @default.
• W1969383564 hasConceptScore W1969383564C142724271 @default.
• W1969383564 hasConceptScore W1969383564C143409427 @default.
• W1969383564 hasConceptScore W1969383564C2777831590 @default.
• W1969383564 hasConceptScore W1969383564C2778173781 @default.

• next