Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969391013> ?p ?o ?g. }
- W1969391013 endingPage "1586" @default.
- W1969391013 startingPage "1580" @default.
- W1969391013 abstract "Reduction of Abeta deposition is a major therapeutic strategy in Alzheimer's disease (AD). The concentration of Abeta in the brain is modulated not only by Abeta production but also by its degradation. One of the proteases involved in the degradation of Abeta peptides is endothelin-converting enzyme (ECE). In this study, we investigated the effects of an intracranial administration of a seroptype 5 recombinant adeno-associated viral vector (rAAV) containing the ECE-1 synthetic gene on amyloid deposition in amyloid precursor protein (APP) plus presenilin-1 (PS1) transgenic mice. The rAAV vector was injected unilaterally into the right anterior cortex and hippocampus of 6-month-old mice, while control mice received an AAV vector expressing green fluorescent protein (GFP). Immunohistochemical testing for the hemagglutinin (HA) tag appended to ECE revealed strong expression in areas surrounding the injection sites but minimal expression in the contralateral regions. Immunohistochemical tests showed that Abeta decreases in the anterior cortex and hippocampus in mice receiving the ECE synthetic gene. Further, decreases in Congo red positive deposits were also observed in both regions. These results indicate that increasing the expression of beta-amyloid degrading enzymes through gene therapy is a promising approach to the treatment of AD." @default.
- W1969391013 created "2016-06-24" @default.
- W1969391013 creator A5017362034 @default.
- W1969391013 creator A5019848579 @default.
- W1969391013 creator A5027284944 @default.
- W1969391013 creator A5028444221 @default.
- W1969391013 creator A5031961106 @default.
- W1969391013 creator A5046928489 @default.
- W1969391013 creator A5055192037 @default.
- W1969391013 creator A5072164893 @default.
- W1969391013 creator A5080326488 @default.
- W1969391013 date "2008-09-01" @default.
- W1969391013 modified "2023-10-18" @default.
- W1969391013 title "Adeno-associated Viral (AAV) Serotype 5 Vector Mediated Gene Delivery of Endothelin-converting Enzyme Reduces Aβ Deposits in APP + PS1 Transgenic Mice" @default.
- W1969391013 cites W1542264365 @default.
- W1969391013 cites W1621971853 @default.
- W1969391013 cites W1965275873 @default.
- W1969391013 cites W1976064239 @default.
- W1969391013 cites W1982006302 @default.
- W1969391013 cites W1987971841 @default.
- W1969391013 cites W1991991142 @default.
- W1969391013 cites W1996525958 @default.
- W1969391013 cites W1998750669 @default.
- W1969391013 cites W2002778911 @default.
- W1969391013 cites W2003456064 @default.
- W1969391013 cites W2007105697 @default.
- W1969391013 cites W2019042091 @default.
- W1969391013 cites W2029532449 @default.
- W1969391013 cites W2031321340 @default.
- W1969391013 cites W2033016640 @default.
- W1969391013 cites W2034860964 @default.
- W1969391013 cites W2045776001 @default.
- W1969391013 cites W2048008983 @default.
- W1969391013 cites W2055920452 @default.
- W1969391013 cites W2060034256 @default.
- W1969391013 cites W2062535497 @default.
- W1969391013 cites W2067998641 @default.
- W1969391013 cites W2077464099 @default.
- W1969391013 cites W2086204662 @default.
- W1969391013 cites W2088479689 @default.
- W1969391013 cites W2096410114 @default.
- W1969391013 cites W2097292535 @default.
- W1969391013 cites W2102502414 @default.
- W1969391013 cites W2105758687 @default.
- W1969391013 cites W2117983251 @default.
- W1969391013 cites W2122741223 @default.
- W1969391013 cites W2129337589 @default.
- W1969391013 cites W2135082924 @default.
- W1969391013 cites W2138935359 @default.
- W1969391013 cites W2143109407 @default.
- W1969391013 cites W2149802841 @default.
- W1969391013 cites W2152286012 @default.
- W1969391013 cites W2152304945 @default.
- W1969391013 cites W2153966730 @default.
- W1969391013 cites W2155133303 @default.
- W1969391013 cites W2157935966 @default.
- W1969391013 cites W2160121070 @default.
- W1969391013 cites W2162929058 @default.
- W1969391013 cites W2343097881 @default.
- W1969391013 cites W4252045980 @default.
- W1969391013 doi "https://doi.org/10.1038/mt.2008.148" @default.
- W1969391013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2706523" @default.
- W1969391013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28189012" @default.
- W1969391013 hasPublicationYear "2008" @default.
- W1969391013 type Work @default.
- W1969391013 sameAs 1969391013 @default.
- W1969391013 citedByCount "60" @default.
- W1969391013 countsByYear W19693910132012 @default.
- W1969391013 countsByYear W19693910132013 @default.
- W1969391013 countsByYear W19693910132014 @default.
- W1969391013 countsByYear W19693910132015 @default.
- W1969391013 countsByYear W19693910132016 @default.
- W1969391013 countsByYear W19693910132017 @default.
- W1969391013 countsByYear W19693910132018 @default.
- W1969391013 countsByYear W19693910132019 @default.
- W1969391013 countsByYear W19693910132020 @default.
- W1969391013 countsByYear W19693910132021 @default.
- W1969391013 countsByYear W19693910132022 @default.
- W1969391013 countsByYear W19693910132023 @default.
- W1969391013 crossrefType "journal-article" @default.
- W1969391013 hasAuthorship W1969391013A5017362034 @default.
- W1969391013 hasAuthorship W1969391013A5019848579 @default.
- W1969391013 hasAuthorship W1969391013A5027284944 @default.
- W1969391013 hasAuthorship W1969391013A5028444221 @default.
- W1969391013 hasAuthorship W1969391013A5031961106 @default.
- W1969391013 hasAuthorship W1969391013A5046928489 @default.
- W1969391013 hasAuthorship W1969391013A5055192037 @default.
- W1969391013 hasAuthorship W1969391013A5072164893 @default.
- W1969391013 hasAuthorship W1969391013A5080326488 @default.
- W1969391013 hasBestOaLocation W19693910131 @default.
- W1969391013 hasConcept C102230213 @default.
- W1969391013 hasConcept C104317684 @default.
- W1969391013 hasConcept C111599444 @default.
- W1969391013 hasConcept C135983454 @default.
- W1969391013 hasConcept C141035611 @default.
- W1969391013 hasConcept C142613039 @default.
- W1969391013 hasConcept C142724271 @default.
- W1969391013 hasConcept C153911025 @default.