Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969398306> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1969398306 endingPage "396" @default.
- W1969398306 startingPage "391" @default.
- W1969398306 abstract "The goal of our study was to determine if endogenous norepinephrine (NE) has a role in the regulation of basal blood flow to intact bone. The experimental plan was to measure bone blood flow before and after pharmacological blockade of alpha-adrenergic receptors. A significant increase in blood flow after receptor blockade would suggest that endogenous norepinephrine exerts a tonic constrictor effect on the vessels supplying blood to the bone. Mature, male rats were anesthetized with Inactin. Arterial blood pressure and left tibia blood flow (laser Doppler flowmetry) were measured. A cannula was inserted into the right iliac artery and advanced to the aortic bifurcation to deliver drugs into the left hindlimb circulation, including the left tibia vasculature. Bolus injection of norepinephrine caused a dose-dependent decrease in bone blood flow (30-40%). Blockade of alpha-adrenergic receptors with phentolamine or phenoxybenzamine attenuated by more than 50% the norepinephrine-induced decrease in bone blood flow. In separate rats that had not received exogenous norepinephrine, injection of phentolamine alone decreased bone vascular resistance by 34+/-3%. Similarly, phenoxybenzamine decreased resistance by 25+/-4%. These results are consistent with the conclusion that alpha-adrenergic receptors mediate a significant constriction of blood vessels which participate in the partial control of basal blood flow to the intact rat tibia." @default.
- W1969398306 created "2016-06-24" @default.
- W1969398306 creator A5008346293 @default.
- W1969398306 creator A5031825430 @default.
- W1969398306 creator A5034552535 @default.
- W1969398306 creator A5051080188 @default.
- W1969398306 creator A5067373513 @default.
- W1969398306 creator A5074131611 @default.
- W1969398306 creator A5083864688 @default.
- W1969398306 date "2002-03-01" @default.
- W1969398306 modified "2023-10-16" @default.
- W1969398306 title "Endogenous norepinephrine regulates blood flow to the intact rat tibia" @default.
- W1969398306 cites W1967216238 @default.
- W1969398306 cites W1971893327 @default.
- W1969398306 cites W1981525959 @default.
- W1969398306 cites W2016637342 @default.
- W1969398306 cites W2039562808 @default.
- W1969398306 cites W2040856583 @default.
- W1969398306 cites W2050819925 @default.
- W1969398306 cites W2064626102 @default.
- W1969398306 cites W2077167257 @default.
- W1969398306 cites W2121554538 @default.
- W1969398306 cites W2128928997 @default.
- W1969398306 cites W2131746089 @default.
- W1969398306 cites W2291844222 @default.
- W1969398306 cites W2298382521 @default.
- W1969398306 cites W2314674831 @default.
- W1969398306 cites W2471999105 @default.
- W1969398306 doi "https://doi.org/10.1016/s0736-0266(01)00121-8" @default.
- W1969398306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11924647" @default.
- W1969398306 hasPublicationYear "2002" @default.
- W1969398306 type Work @default.
- W1969398306 sameAs 1969398306 @default.
- W1969398306 citedByCount "11" @default.
- W1969398306 countsByYear W19693983062013 @default.
- W1969398306 countsByYear W19693983062014 @default.
- W1969398306 countsByYear W19693983062015 @default.
- W1969398306 countsByYear W19693983062019 @default.
- W1969398306 countsByYear W19693983062020 @default.
- W1969398306 countsByYear W19693983062023 @default.
- W1969398306 crossrefType "journal-article" @default.
- W1969398306 hasAuthorship W1969398306A5008346293 @default.
- W1969398306 hasAuthorship W1969398306A5031825430 @default.
- W1969398306 hasAuthorship W1969398306A5034552535 @default.
- W1969398306 hasAuthorship W1969398306A5051080188 @default.
- W1969398306 hasAuthorship W1969398306A5067373513 @default.
- W1969398306 hasAuthorship W1969398306A5074131611 @default.
- W1969398306 hasAuthorship W1969398306A5083864688 @default.
- W1969398306 hasBestOaLocation W19693983061 @default.
- W1969398306 hasConcept C126322002 @default.
- W1969398306 hasConcept C134018914 @default.
- W1969398306 hasConcept C158846371 @default.
- W1969398306 hasConcept C170493617 @default.
- W1969398306 hasConcept C185592680 @default.
- W1969398306 hasConcept C2778514916 @default.
- W1969398306 hasConcept C2780253649 @default.
- W1969398306 hasConcept C2780668150 @default.
- W1969398306 hasConcept C513476851 @default.
- W1969398306 hasConcept C58245268 @default.
- W1969398306 hasConcept C71924100 @default.
- W1969398306 hasConcept C84393581 @default.
- W1969398306 hasConceptScore W1969398306C126322002 @default.
- W1969398306 hasConceptScore W1969398306C134018914 @default.
- W1969398306 hasConceptScore W1969398306C158846371 @default.
- W1969398306 hasConceptScore W1969398306C170493617 @default.
- W1969398306 hasConceptScore W1969398306C185592680 @default.
- W1969398306 hasConceptScore W1969398306C2778514916 @default.
- W1969398306 hasConceptScore W1969398306C2780253649 @default.
- W1969398306 hasConceptScore W1969398306C2780668150 @default.
- W1969398306 hasConceptScore W1969398306C513476851 @default.
- W1969398306 hasConceptScore W1969398306C58245268 @default.
- W1969398306 hasConceptScore W1969398306C71924100 @default.
- W1969398306 hasConceptScore W1969398306C84393581 @default.
- W1969398306 hasIssue "2" @default.
- W1969398306 hasLocation W19693983061 @default.
- W1969398306 hasLocation W19693983062 @default.
- W1969398306 hasOpenAccess W1969398306 @default.
- W1969398306 hasPrimaryLocation W19693983061 @default.
- W1969398306 hasRelatedWork W1935296326 @default.
- W1969398306 hasRelatedWork W1966326317 @default.
- W1969398306 hasRelatedWork W1971417031 @default.
- W1969398306 hasRelatedWork W2002417562 @default.
- W1969398306 hasRelatedWork W2042460860 @default.
- W1969398306 hasRelatedWork W2072596536 @default.
- W1969398306 hasRelatedWork W2397641144 @default.
- W1969398306 hasRelatedWork W2466473011 @default.
- W1969398306 hasRelatedWork W2911419343 @default.
- W1969398306 hasRelatedWork W1964945504 @default.
- W1969398306 hasVolume "20" @default.
- W1969398306 isParatext "false" @default.
- W1969398306 isRetracted "false" @default.
- W1969398306 magId "1969398306" @default.
- W1969398306 workType "article" @default.