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- W1969404639 abstract "We have synthesized a spin-labeled derivative of ET-18-OCH3, a known antitumor ether-linked phospholipid. The spin-labeled analog was shown to be as potent as ET-18-OCH3 in inhibiting 3H-thymidine uptake of HL60 leukemic cells. Electron spin resonance (ESR) studies showed that the mobility of this ether-linked phospholipid in the membrane is more restricted when compared to its ester-linked counterparts. It is probable that the absence of the bulky carbonyl oxygens allows closer packing of the two alkyl chains in the ether-linked phospholipid, thereby reducing the angular amplitude of the motion of the alkyl chains. These findings may be of importance in elucidating mechanisms by which the antitumor ether-linked phospholipids perturb the structure of cellular membranes." @default.
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- W1969404639 date "1989-05-01" @default.
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- W1969404639 title "Molecular dynamics of antitumor ether-linked phospholipids in model membranes: A spin-label study" @default.
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- W1969404639 doi "https://doi.org/10.1016/s0006-291x(89)80129-9" @default.
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