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• W1969408052 abstract "ObjectiveProgesterone (P4) suppresses uterine contractility (CTX) and is used to prevent recurrent preterm labor. Nitric oxide (NO) also inhibits CTX in experimental and clinical studies. Our objectives were to compare the effects of P4 to sodium nitroprusside (SNP, an NO donor) and their combination on human CTX of term/preterm and labor/nonlabor tissues to determine if there are additional effects of the two agents when used together.Study DesignUterine tissues (n=128) from women (n=16) undergoing Cesarean section at term not in labor were suspended in organ baths. Tissues (n 6/group) were treated with vehicle, P4, SNP, or combinations. A subset of tissues (n 2, per group) from term labor, preterm no labor, and nonpregnant specimens were analyzed with P4 alone. Area under the contractions curves were analyzed every 30 min. ANOVA was used for statistical differences (P<0.05).ResultsP4 (10-4M) and SNP (10-5M) treatment alone significantly inhibit CTX after 1 hour. The combination of P4 treatment with SNP (both at 10-5 M) significantly suppresses CTX (% inhibition of −127.1 ± 14.5, P = 0.009) to levels lower than with either P4 (−20.1 ± 8.6) or SNP alone (−72.0 ± 11.2). P4 (10-4M) has similar levels of suppression of CTX in term no labor/labor (−57 ± 9 and −91 ± 8), preterm no labor (−70 ± 8), and nonpregnant (−75 ± 9) tissues.ConclusionP4 directly suppresses uterine CTX probably by nongenomic mechanisms. Similarly SNP inhibits CTX possibly by stimulating guanylate cyclase. In combination, there is a significant additive effect, which supports the concept that each acts on separate pathways to inhibit CTX. In addition, P4 effectively inhibits contractility during both labor/nonlabor states. This study indicates that P4 or SNP alone may be used treat or prevent preterm labor and their combination may be more successful. ObjectiveProgesterone (P4) suppresses uterine contractility (CTX) and is used to prevent recurrent preterm labor. Nitric oxide (NO) also inhibits CTX in experimental and clinical studies. Our objectives were to compare the effects of P4 to sodium nitroprusside (SNP, an NO donor) and their combination on human CTX of term/preterm and labor/nonlabor tissues to determine if there are additional effects of the two agents when used together. Progesterone (P4) suppresses uterine contractility (CTX) and is used to prevent recurrent preterm labor. Nitric oxide (NO) also inhibits CTX in experimental and clinical studies. Our objectives were to compare the effects of P4 to sodium nitroprusside (SNP, an NO donor) and their combination on human CTX of term/preterm and labor/nonlabor tissues to determine if there are additional effects of the two agents when used together. Study DesignUterine tissues (n=128) from women (n=16) undergoing Cesarean section at term not in labor were suspended in organ baths. Tissues (n 6/group) were treated with vehicle, P4, SNP, or combinations. A subset of tissues (n 2, per group) from term labor, preterm no labor, and nonpregnant specimens were analyzed with P4 alone. Area under the contractions curves were analyzed every 30 min. ANOVA was used for statistical differences (P<0.05). Uterine tissues (n=128) from women (n=16) undergoing Cesarean section at term not in labor were suspended in organ baths. Tissues (n 6/group) were treated with vehicle, P4, SNP, or combinations. A subset of tissues (n 2, per group) from term labor, preterm no labor, and nonpregnant specimens were analyzed with P4 alone. Area under the contractions curves were analyzed every 30 min. ANOVA was used for statistical differences (P<0.05). ResultsP4 (10-4M) and SNP (10-5M) treatment alone significantly inhibit CTX after 1 hour. The combination of P4 treatment with SNP (both at 10-5 M) significantly suppresses CTX (% inhibition of −127.1 ± 14.5, P = 0.009) to levels lower than with either P4 (−20.1 ± 8.6) or SNP alone (−72.0 ± 11.2). P4 (10-4M) has similar levels of suppression of CTX in term no labor/labor (−57 ± 9 and −91 ± 8), preterm no labor (−70 ± 8), and nonpregnant (−75 ± 9) tissues. P4 (10-4M) and SNP (10-5M) treatment alone significantly inhibit CTX after 1 hour. The combination of P4 treatment with SNP (both at 10-5 M) significantly suppresses CTX (% inhibition of −127.1 ± 14.5, P = 0.009) to levels lower than with either P4 (−20.1 ± 8.6) or SNP alone (−72.0 ± 11.2). P4 (10-4M) has similar levels of suppression of CTX in term no labor/labor (−57 ± 9 and −91 ± 8), preterm no labor (−70 ± 8), and nonpregnant (−75 ± 9) tissues. ConclusionP4 directly suppresses uterine CTX probably by nongenomic mechanisms. Similarly SNP inhibits CTX possibly by stimulating guanylate cyclase. In combination, there is a significant additive effect, which supports the concept that each acts on separate pathways to inhibit CTX. In addition, P4 effectively inhibits contractility during both labor/nonlabor states. This study indicates that P4 or SNP alone may be used treat or prevent preterm labor and their combination may be more successful. P4 directly suppresses uterine CTX probably by nongenomic mechanisms. Similarly SNP inhibits CTX possibly by stimulating guanylate cyclase. In combination, there is a significant additive effect, which supports the concept that each acts on separate pathways to inhibit CTX. In addition, P4 effectively inhibits contractility during both labor/nonlabor states. This study indicates that P4 or SNP alone may be used treat or prevent preterm labor and their combination may be more successful." @default.
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• W1969408052 title "462: Additive inhibitory effects of progesterone and sodium nitroprusside on uterine contractility during pregnancy" @default.
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